Active Ingredient History
Deferasirox (marketed as Exjade, Desirox, Deferasirox) is an iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. It is the first oral medication approved for this purpose in the USA by FDA in November 2005. It is approved in the European Union by the European Medicines Agency (EMA) for children 6 years and older for chronic iron overload from repeated blood transfusions. Deferasirox is highly selective for iron as Fe3+. In approximately 1-year clinical trials of patients with transfusional chronic iron overload associated with beta-thalassaemia, sickle cell disease, myelodysplastic syndrome or other rare chronic anaemias, deferasiroxhad a beneficial effect on liver iron concentrations (LIC) and serum ferritin levels. Deferasirox can cause acute renal failure, fatal in some patients and requiring dialysis in others. It was showed that most fatalities occurred in patients with multiple comorbidities in advanced stages of their hematological disorders. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
beta-Thalassemia (approved 2005)
Iron Overload (approved 2005)
Anemia (Phase 4)
Anemia, Aplastic (Phase 4)
Anemia, Diamond-Blackfan (Phase 4)
Anemia, Hemolytic (Phase 2)
Anemia, Sickle Cell (Phase 4)
Ascorbic Acid (Phase 2/Phase 3)
beta-Thalassemia (Phase 4)
Blood Transfusion (Phase 4)
Breast Neoplasms (Phase 2)
Fanconi Syndrome (Phase 2)
Healthy Volunteers (Phase 1)
Hemochromatosis (Phase 2)
Hemoglobinopathies (Phase 4)
Hemosiderosis (Phase 4)
Iron Metabolism Disorders (Phase 2)
Iron Overload (Phase 4)
Leukemia (Phase 2)
Leukemia, Myeloid, Acute (Phase 2)
Liver Diseases (Phase 1)
Lymphoma (Phase 2)
Metabolic Diseases (Phase 2)
Mucormycosis (Phase 2)
Multiple Myeloma (Phase 2)
Neuroblastoma (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 1/Phase 2)
Osteoporosis, Postmenopausal (Phase 2)
Ovarian Neoplasms (Phase 2)
Porphyria Cutanea Tarda (Phase 3)
Primary Myelofibrosis (Phase 3)
Thalassemia (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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