clevidipine (cleviprex) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Clevidipine is a dihydropyridine calcium channel blocker. Clevidipine is marketed under the trade name Cleviprex, indicated for the reduction of blood pressure (BP) when oral therapy is not feasible or not desirable. Clevidipine is a dihydropyridine L-type calcium channel blocker. L-type calcium channels mediate the influx of calcium during depolarization in arterial smooth muscle. Experiments in anesthetized rats and dogs show that clevidipine reduces mean arterial blood pressure by decreasing systemic vascular resistance. Clevidipine does not reduce cardiac filling pressure (pre-load), confirming lack of effects on the venous capacitance vessels.   NCATS

Chemistry

  • SMILES: CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(Cl)=C2Cl)C(=O)OC
  • InChIKey: KPBZROQVTHLCDU-UHFFFAOYSA-N
  • Mol. Mass: 456.316
  • ALogP: 4.25
  • ChEMBL Molecule:
    clevidipine  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$0.9053 - $45.7480
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | clevelox | clevidipine | clevidipine butyrate | cleviprex

Organizations (26)

Research & Development (26)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (20)

Approved Indications (1)


 

Hypertension (approved 2008)

Experimental Indications - Clinical Trial Phases 1-4 (20)


 

Aortic Aneurysm (Phase 4)

Aortic Diseases (Phase 4)

Blood Pressure (Phase 4)

Brain Neoplasms (Phase 4)

Critical Illness (Phase 2)

Dyspnea (Phase 3)

Epilepsy (Phase 4)

Heart Failure (Phase 3)

Hemorrhage (Phase 3)

Hypertension (Phase 4)

Hypertension, Pulmonary (Phase 4)

Intracranial Aneurysm (Phase 2)

Intracranial Hemorrhages (Phase 4)

Scoliosis (Phase 2/Phase 3)

Stroke (Phase 3)

Subarachnoid Hemorrhage (Phase 4)

Thrombosis (Phase 3)

Traumatology (Phase 4)

Vascular Diseases (Early Phase 1)

Vasospasm, Intracranial (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 30
  • # of Trial Organizations: 26

Trials by Phase

Trial Phase Start Date Organizations Indications

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