capreomycin (capastat) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Capreomycin is an antibiotic, which is used in combination other antituberculosis drugs fro the treatment of pulmonary infections caused by capreomycin-susceptible strains of M. tuberculosis when the primary agents (isoniazid, rifampin, ethambutol, aminosalicylic acid, and streptomycin) have been ineffective or cannot be used because of toxicity or the presence of resistant tubercle bacilli. Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins.   NCATS

Chemistry

  • SMILES: C[C@@H]1NC(=O)[C@@H](N)CNC(=O)[C@H](C2CCNC(=N)N2)NC(=O)/C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)CC(N)CCCN)NC1=O.N=C1NCCC([C@@H]2NC(=O)/C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)CC(N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC2=O)N1
  • InChIKey: VCOPTHOUUNAYKQ-DAOVIKHBSA-N
  • Mol. Mass: 1321.44
  • ALogP: Missing data
  • ChEMBL Molecules:
    capreomycin  
    capreomycin sulfate  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$0.0100
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

34977 | capastat | capastat sulfate | capostatin | capreomicin | capreomycin | capreomycine | capreomycine sulfate | capreomycin sulfate | capromycin

Organizations (10)

Research & Development (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (2)


 

Tuberculosis

Tuberculosis, Pulmonary (approved 1971)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

HIV Infections (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 3
  • # of Trial Organizations: 5

Trials by Phase

Trial Phase Start Date Organizations Indications

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