flavone Report issue

Small molecule Experimental

Active Ingredient History

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Flavone belongs to the class of organic compounds known as flavones. Flavones are mainly found in cereals and herbs. Flavone is a less potent inhibitor of CYP1A1 than CYP1A2. Flavone inhibited the estrogen action without binding to the estrogen receptor by acting as a competitive agonist for aryl hydrocarbon receptor. This naturally occurring flavone was shown to be an effective inducer of benzpyrene hydroxylase in human liver microsomes in in vitro assays, and the inducing effect of the flavone was concentration-dependent.   NCATS

Chemistry

  • SMILES: O=C1C=C(OC2=C1C=CC=C2)C3=CC=CC=C3
  • InChIKey: VHBFFQKBGNRLFZ-UHFFFAOYSA-N
  • Mol. Mass: 222.2387
  • ALogP: 3.46
  • ChEMBL Molecule:
    flavone  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Organizations (1)

Research & Development (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Inflammation (Phase 1)

Periodontal Diseases (Phase 1)

Overview

  • Highest Phase: Phase 1
  • # of Trials: 1
  • # of Trial Organizations: 1

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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