pyridoxal phosphate anhydrous Report issue

Small molecule Experimental

Active Ingredient History

NOW
  • Now
Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P) is a coenzyme, the active form of vitamin B6. Pyridoxal 5′-phosphate (PLP) is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates. PLP acts as a coenzyme in all transamination reactions, in various beta-elimination reactions, in the condensation reaction in heme synthesis.   NCATS

Chemistry

  • SMILES: CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O
  • InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
  • Mol. Mass: 247.1419
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Missing data
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: Missing data

Organizations (2)

Research & Development (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (7)

Approved Indications (1)


 

Vitamin B 6 Deficiency

Experimental Indications - Clinical Trial Phases 1-4 (6)


 

Deficiency Diseases (Phase 3)

Diabetes Mellitus, Type 2 (Phase 2)

Digestion ()

Metabolic Syndrome (Phase 2)

Pregnancy Complications (Phase 4)

Tardive Dyskinesia (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 2
  • # of Trial Organizations: 2

Trials by Phase

Trial Phase Start Date Organizations Indications

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