API | Raltitrexed

Raltitrexed (Tomudex) Report issue

Small molecule Experimental

AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW

Raltitrexed is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. ^Wikipedia

Chemistry

SMILES: Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)ccc2[nH]1
InChIKey: IVTVGDXNLFLDRM-HNNXBMFYSA-N
Mol. Mass: 458.5
ALogP: 1.98 Partition coefficient
ChEMBL Molecule:
raltitrexed

More Chemistry

Pharmacology

Mechanism of Action:
- Thymidylate synthase (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Parenteral
Pro Drug: No

Drug Pricing (per unit)

Australia

$202.1285

More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

arkomédika brand of raltitrexed | astrazeneca brand of raltitrexed | d1694 | d 1694 | d-1694 | ici d1694 | ici-d1694 | n-(5-(n-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-n-methylamino)-2-thenoyl)-l-glutamic acid | ralitrexed | raltitrexed | tomudex | zd-16 | zd1694 | zd 1694 | zd-1694 | zeneca brand of raltitrexed

Organizations (55)

Research & Development (55)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (23)

Approved Indications (1)

Colorectal Neoplasms

Experimental Indications - Clinical Trial Phases 1-4 (23)

Adenocarcinoma (Phase 2)

Adenoma (Phase 2)

Carcinoma, Hepatocellular (Phase 3)

Chemoembolization, Therapeutic (Phase 2)

Colonic Neoplasms (Phase 2)

Colorectal Neoplasms (Phase 4)

Drugs, Investigational (Phase 1/Phase 2)

Esophageal Neoplasms (Phase 2)

Herpes Simplex ()

Hyperthermic Intraperitoneal Chemotherapy (Phase 1)

Leukemia, Myeloid, Acute (Phase 1)

Liver Neoplasms (Phase 4)

Mesothelioma, Malignant (Phase 3)

Nasopharyngeal Carcinoma (Phase 2)

Neoplasm Metastasis (Phase 3)

Neoplasms ()

Pancreatic Neoplasms (Phase 2)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 1)

Rectal Neoplasms (Phase 2)

Squamous Cell Carcinoma of Head and Neck (Phase 4)

Stomach Neoplasms (Phase 2)

Thrombocytopenia (Phase 2)

Overview

Highest Phase: Phase 4
# of Trials: 50
# of Trial Organizations: 55

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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