API | antithrombin (Recombinant)

antithrombin (Recombinant) (ATryn) Report issue

Biologics Recombinant protein Orphan Drug ^FDA Approved ^FDA

AACT ChEMBL DrugBank

Active Ingredient History

NOW

ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company rEVO Biologics. It is made from the milk of goats that have been genetically modified to produce human antithrombin, a plasma protein with anticoagulant properties. Microinjection was used to insert human antithrombin genes into the cell nucleus of their embryos. ATryn is the first medicine produced using genetically engineered animals. GTC states that one genetically modified goat can produce the same amount of antithrombin in a year as 90,000 blood donations. GTC chose goats for the process because they reproduce more rapidly than cattle and produce more protein than rabbits or mice. ^Wikipedia

Chemistry

SMILES: Missing data
InChIKey: Missing data
Mol. Mass: Missing data
ALogP: Missing data
ChEMBL Molecule:
antithrombin alfa

More Chemistry

Pharmacology

Mechanism of Action:
- Tumor necrosis factor ligand superfamily member 4 (Homo sapiens) ^UniProt
Multi-specific: No
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

antithrombin iii,recombinant | antithrombin iii, recombinant | antithrombin (recombinant) | atryn | recombinant antithrombin

Organizations (3)

Research & Development (1)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (2)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (1)

Approved Indications (1)

Antithrombin III Deficiency (approved 2009)

Experimental Indications - Clinical Trial Phases 1-4 (0)

Overview

Highest Phase: Phase 3
# of Trials: 1
# of Trial Organizations: 1

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

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