API | o-desmethyltramadol

o-desmethyltramadol Report issue

Small molecule Experimental

AACT

Active Ingredient History

NOW

Desmetramadol, also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite of tramadol. Tramadol is demethylated by the liver enzyme CYP2D6 to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form of CYP2D6 will tend to have reduced analgesic effects from tramadol. Because desmetramadol itself does not need to be metabolized to induce an analgesic effect, it can be used in individuals with low CYP2D6 activity unlike tramadol. ^Wikipedia

Chemistry

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More Chemistry

Pharmacology

Mechanism of Action:
- Mu-type opioid receptor (Homo sapiens) ^UniProt
Multi-specific: Missing data
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Pro Drug: Missing data

o-desmethyltramadol

Organizations (3)

Research & Development (3)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (3)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (3)

Chronic Pain (Phase 2)

Diabetic Neuropathies (Phase 2)

Neuralgia (Phase 2)

Overview

Highest Phase: Phase 2
# of Trials: 1
# of Trial Organizations: 3

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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