nirogacestat (Ogsiveo) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Breakthrough Therapy FDA Priority Review FDA
AACT DrugBank MeSH PubChem

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Chemistry

Mol. Mass

489.66

ALogP

4.79

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1
  • InChIKey: VFCRKLWBYMDAED-REWPJTCUSA-N
    InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1
  • Chirality: Single Stereoisomer
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL1770916   ChEMBL
nirogacestat *

CHEMBL4298153   ChEMBL
nirogacestat hydrobromide

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