thiamylal (surital) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

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Thiamylal is a barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. Thiamylal, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia. Thiamylal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.   NCATS

Chemistry

  • SMILES: C=CCC1(C(C)CCC)C(=O)NC(=S)NC1=O
  • InChIKey: XLOMZPUITCYLMJ-UHFFFAOYSA-N
  • Mol. Mass: 254.35
  • ALogP: 1.52
  • ChEMBL Molecules:
    thiamylal  
    thiamylal sodium  
More Chemistry

Pharmacology

Alternative names

5-allyl-5-(1-methylbutyl)-2-thiobarbituric acid | 5-allyl-5-(1-methylbutyl)-2-thioxodihydro-4,6(1h,5h)-pyrimidinedione | 5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1h,5h)-dione | dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1h,5h)-pyrimidinedione | surital | thiamylal | thiamylal sodium | thioquinalbarbitone | thioseconal

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Indications (1)

Approved Indications (1)


 

Pain (approved 1951)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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