nomifensine (Merital) Report issue

Small molecule Withdrawn
ChEMBL DrugBank Drug Central KEGG MeSH PubChem

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Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. This is a mechanism of action shared by some recreational drugs like cocaine and the medication tametraline (see DRI). Research showed that the (S)-isomer is responsible for activity.   Wikipedia

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Pharmacology

Alternative names

2-methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine | 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinolin | 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline | 8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline | hoe-984 | linamiphen | merital | nomifensin | (+-)-nomifensin | (+/-)-nomifensin | nomifensina | nomifensine | (+-)-nomifensine | (+/-)-nomifensine | (+)-nomifensine | nomifensine maleate | nomifensinum | (+)-nomiphensine | (r)-1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine

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Indications (1)

Approved Indications (1)


 

Depression (approved 1984)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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