diphenylpyraline (hispril) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Diphenylpyraline is an antihistamine that prevents but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa. Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No

Alternative names

1-methyl-4-hydroxypiperidine benzhydryl ether | 1-methyl-4-piperidyl benzhydryl ether | 4-(benzhydryloxy)-1-methylpiperidine | 4-(benzhydryloxy)-n-methylpiperidine | 4-diphenylmethoxy-1-methylpiperidine | difenilpiralina | diphenpyraline | diphenylpyralamine | diphenylpyraline | diphenylpyraline hcl | diphenylpyraline hydrochloride | diphenylpyraline maleate | diphenylpyraline maleate (2:1) | diphenylpyraline teoclate | diphenylpyralinum | diphenylpyrilene | hispril | histryl | histryl paed | lergoban | lergobine

Organizations (2)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (3)


 

Pruritus

Rhinitis

Rhinitis, Allergic, Seasonal

Experimental Indications - Clinical Trial Phases 1-4 (0)

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