sulphaphthalyl Report issue

Small molecule Experimental
ChEMBL Drug Central KEGG MeSH PubChem

Active Ingredient History

Phthalylsulfathiazole is a sulfonamide antibiotic. Phthalylsulfathiazole is an effective remedy in the treatment of dysentery, diarrhea and other intestinal fluxes. It inhibits dihydropteroate synthetase activity of bacteria. In veterinary, it is used for the treatment of diarrhea and enteritis of the calves, dysentery in sheep, gastroenteritis in foals and adult equines, enteritis caused by food poisoning. Phthalylsulfathiazole is only slightly absorbed from the gut, about 5 percent of the quantity ingested being eliminated in the urine. Consequently, it produces little or no systemic effects with virtually no risk of crystalluria, haematuria or oliguria. In hyper-susceptible people, it may cause gastrointestinal side effects, like nausea, vomiting, etc.   NCATS

Chemistry

  • SMILES: OC(=O)C1=CC=CC=C1C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3
  • InChIKey: PBMSWVPMRUJMPE-UHFFFAOYSA-N
  • Mol. Mass: 403.432
  • ALogP: 2.89
  • ChEMBL Molecule:
    phthalylsulfathiazole  
More Chemistry

Pharmacology

Alternative names

cremothalidine | enteramida | entexidina | ftalazol | phtalazol | phthalazol | phthalylnorsulfazole | phthalylsulfathiazole | phthalylsulfathiazole monosodium salt | phthalylsulfathiazole sodium | phthalylsulfhathiazole | phthalylsulfonazole | phthalylsulphathiazole | sulfaphtalylthiazol | sulfaphthalazole | sulfathalidine | sulphaphthalyl | thalazole

Indications (3)

Approved Indications (3)


 

Diarrhea

Dysentery

Gastroenteritis

Experimental Indications - Clinical Trial Phases 1-4 (0)

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