sertaconazole (ertaczo) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Sertaconazole is a azole antifungal that is FDA approved for the treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by: Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Common adverse reactions include contact dermatitis, dry skin, burning skin and application site skin tenderness.   NCATS

Chemistry

  • SMILES: Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1
  • InChIKey: JLGKQTAYUIMGRK-UHFFFAOYSA-N
  • Mol. Mass: 437.78
  • ALogP: 7.02
  • ChEMBL Molecules:
    sertaconazole  
    sertaconazole nitrate  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$11.2220 - $12.9700
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

demofix | dermofix | dermoseptic | ertaczo | fi 7045 | fi-7045 | ginedermofix | mykosert | sertaconazol | sertaconazole | sertaconazole nitrate | sertaconazolum | zalain

Organizations (5)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (4)

Approved Indications (1)


 

Tinea Pedis (approved 2003)

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Dermatitis, Atopic (Phase 2)

Foot (Phase 3)

Tinea (Phase 3)

Tinea Pedis (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 2
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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