cloxacillin (pathocil) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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  • Now
Cloxacillin is a derivative of penicillin for the treatment of broad spectrum of bacterial infections. The drug exerts its action by inhiiting bacterial beta-lactamase (penicillin-binding proteins).   NCATS

Chemistry

  • SMILES: Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O
  • InChIKey: LQOLIRLGBULYKD-JKIFEVAISA-N
  • Mol. Mass: 435.89
  • ALogP: 2.55
  • ChEMBL Molecules:
    cloxacillin  
    cloxacillin sodium  
More Chemistry

Pharmacology

Alternative names

(2s,5r,6r)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | (3-(o-chlorophenyl)-5-methyl-4-isoxazolyl)penicillin | 6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid | brl-1621 | cloxacilina | cloxacillin | cloxacilline | cloxacillin sodium | cloxacillin sodium salt | cloxacillinum | cloxapen | dariclox | ekvacillin | methocillin s | orbenin | p-25 | tegopen

Organizations (20)

Research & Development (16)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (19)

Approved Indications (9)


 

Arthritis, Infectious (approved 1982)

Endocarditis, Bacterial (approved 1982)

Meningitis, Bacterial (approved 1982)

Osteomyelitis (approved 1982)

Otitis Media (approved 1982)

Respiratory Tract Infections (approved 1982)

Sepsis (approved 1982)

Skin Diseases, Infectious (approved 1982)

Urinary Tract Infections (approved 1982)

Experimental Indications - Clinical Trial Phases 1-4 (12)


 

Abscess (Phase 4)

Arthritis, Infectious (Phase 4)

Central Nervous System Infections (Phase 4)

Dermatology (Phase 4)

Diabetes Mellitus (Phase 4)

Endocarditis (Phase 3)

Gram-Positive Bacterial Infections (Phase 2)

Kidney Failure, Chronic (Phase 4)

Osteomyelitis (Phase 4)

Staphylococcal Infections (Phase 4)

Staphylococcus (Phase 3)

Staphylococcus aureus (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 12
  • # of Trial Organizations: 16

Trials by Phase

Trial Phase Start Date Organizations Indications

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