Active Ingredient History

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Fenoldopam (marketed under the brand name Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. Fenoldopam Mesylate Injection, USP is indicated for the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.   NCATS

  • SMILES: Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
  • InChIKey: TVURRHSHRRELCG-UHFFFAOYSA-N
  • Mol. Mass: 305.76
  • ALogP: 2.73
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No
corlopam | fenoldopam | fénoldopam | fenoldopam hydrobromide | fenoldopam mesilate | fenoldopam mesylate | fenoldopamum | sk-82526 | sk-82526-j | sk&f-82526 | sk&f-82526j

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