Active Ingredient History
Fenoldopam (marketed under the brand name Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. Fenoldopam Mesylate Injection, USP is indicated for the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. NCATS
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Hypertension (approved 1997)
Acute Kidney Injury (Phase 4)
Arteries (Phase 2/Phase 3)
Cardiac Surgical Procedures (Phase 2)
Cardiopulmonary Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
General Surgery (Phase 2)
Heart Diseases (Phase 4)
Hypertension (Phase 1)
Kidney Diseases (Phase 2/Phase 3)
Kidney Failure, Chronic (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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