Active Ingredient History
Abaloparatide (brand name Tymlos) is a human parathyroid hormone related peptide [PTHrP(1-34)] analog indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture. Abaloparatide is a PTHrP(1-34) analog which acts as an agonist at the PTH1 receptor (PTH1R). This results in activation of the cAMP signaling pathway in target cells. In rats and monkeys, abaloparatide had an anabolic effect on bone, demonstrated by increases in BMD and bone mineral content (BMC) that correlated with increases in bone strength at vertebral and/or nonvertebral sites. Abaloparatide was approved in April 28, 2017 by the FDA (as Tymlos) for the treatment of postmenopausal women with osteoporosis at high risk for fracture. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Arthroplasty, Replacement, Knee (Phase 4)
Femoral Fractures (Phase 4)
Fractures, Bone (Phase 2)
Healthy Volunteers (Phase 1)
Intervertebral Disc Degeneration (Phase 2)
Leukemia, Myelomonocytic, Chronic (Phase 1)
Myelodysplastic Syndromes (Phase 1)
Osteoporosis ()
Osteoporosis, Postmenopausal (Phase 4)
Spinal Fusion (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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