terfenadine (Seldane) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Terfenadine under brand name Seldane was used for the treatment of allergic rhinitis and allergic skin disorders but was withdrawn because of the serious side effect, heart rhythm problems. Terfenadine is a potent antagonist of histamine H1-receptor-mediated responses.   NCATS

Chemistry

  • SMILES: CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4
  • InChIKey: GUGOEEXESWIERI-UHFFFAOYSA-N
  • Mol. Mass: 471.6734
  • ALogP: 6.45
  • ChEMBL Molecule:
    terfenadine  
More Chemistry

Pharmacology

Alternative names

antihistamine | histafen | histafen 120 | racemic terfenadine | rmi-9918 | (rs)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol | seldane | terfenadin | terfenadina | terfenadine | terfénadine | terfenadinum | terfenor | terfenor fte | terfex | terfinax 120 | terfinax 60 | ternadin | triludan | triludan fte

Organizations (1)

Research & Development (0)

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Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (1)

Approved Indications (1)


 

Hypersensitivity, Immediate (approved 1985)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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