secobarbital (seconal) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Secobarbital sodium, a barbiturate, is FDA approved for the treatment of insomnia and for pre-anesthetic use. This drug binds at a distinct site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Adverse reactions are drowsiness, lethargy, hangover, paradoxical excitement in elderly patients, somnolence. Rifampin may decrease secobarbital levels by increasing metabolism.   NCATS

Chemistry

  • SMILES: C=CCC1(C(C)CCC)C(=O)NC(=O)NC1=O
  • InChIKey: KQPKPCNLIDLUMF-UHFFFAOYSA-N
  • Mol. Mass: 238.29
  • ALogP: 1.35
  • ChEMBL Molecules:
    secobarbital  
    secobarbital sodium  
More Chemistry

Pharmacology

Alternative names

5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrione | 5-allyl-5-(1-methylbutyl)-2,4,6(1h,3h,5h)-pyrimidinetrione | 5-allyl-5-(1-methylbutyl)barbituric acid | 5-allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1h,3h,5h)-trione | evronal | hypotrol | immenox | meballymal | quinalbarbital | quinalbarbitone | quinalbarbitone sodium | quinobarbitone | secobarbital | (+-)-secobarbital | (±)-secobarbital | secobarbital sodium | secobarbitalum | secobarbitone | seconal | seconal sodium | seconesin

Organizations (18)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (18)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (3)


 

Migraine Disorders

Preanesthetic Medication (approved 1983)

Sleep Initiation and Maintenance Disorders (approved 1983)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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