gallamine (flaxedil) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

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Gallamine triethiodide is a synthetic nondepolarizing blocking drug, which is allosteric antagonist of muscarinic M2 acetylcholine receptor and inhibitor of acetylcholinesterase. It was used under brand name flaxedil to stabilize muscle contractions during surgical procedures. However, this usage was discontinued. It was shown, that gallamine caused tachycardia by depressing the vagus nerve and, occasionally, hypertension and increased cardiac output.   NCATS

Chemistry

  • SMILES: CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC
  • InChIKey: OZLPUNFFCJDMJD-UHFFFAOYSA-N
  • Mol. Mass: 510.83
  • ALogP: 5.45
  • ChEMBL Molecules:
    gallamine  
    gallamine triethiodide  
More Chemistry

Pharmacology

Alternative names

benzcurine iodide | flaxedil | gallamine | gallamine triethiodide | gallamine triethochloride | gallamine triethyl iodide | gallamini triethiodidum | gallamin triethiodid | gallamone triethiodide | gallamonium iodide | gallomone triethiodide | relaxan | triéthiodure de gallamine | trietioduro de galamina

Organizations (1)

Research & Development (0)

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Marketing (1)

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Indications (1)

Approved Indications (1)


 

Muscle Contraction

Experimental Indications - Clinical Trial Phases 1-4 (0)

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