ethotoin (peganone) Report issue

Small molecule Approved FDA Priority Review FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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  • Now
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin inhibits nerve impulses in the motor cortex by lowering sodium ion influx, limiting tetanic stimulation. Ethotoin is used for the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures. Ethotoin is marketed as Peganone by Ovation.   NCATS

Chemistry

  • SMILES: CCN1C(=O)NC(C1=O)C2=CC=CC=C2
  • InChIKey: SZQIFWWUIBRPBZ-UHFFFAOYSA-N
  • Mol. Mass: 204.2252
  • ALogP: 1.3
  • ChEMBL Molecule:
    ethotoin  
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Pharmacology

Drug Pricing (per unit)

United States

$1.7055
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

1-ethyl-2,5-dioxo-4-phenylimidazolidine | 2,4-imidazolidinedione, 3-ethyl-5-phenyl- | 3-ethyl-5-phenyl-2,4-imidazolidinedione | (+-)-3-ethyl-5-phenylhydantoin | 3-ethyl-5-phenylhydantoin | 3-ethyl-5-phenylimidazolidin-2,4-dione | 3-ethyl-5-phenyl-imidazolidine-2,4-dione | abbott brand of ethotoin | accenon | ethotoin | ethotoïne | ethotoinum | etotoina | peganone

Organizations (1)

Research & Development (0)

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Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (2)


 

Epilepsy (approved 1957)

Seizures

Experimental Indications - Clinical Trial Phases 1-4 (0)

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