crotamiton Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Crotamiton (N-ethyl-N-(2-methylphenyl) but-2-enamide) is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. Crotamiton is a mixture of the cis (Z) and trans (E) isomers. Crotamiton contains not less than 96.0 per cent and not more than the equivalent of 102.0 per cent of N-ethyl-N-(2-methylphenyl)but-2-enamide, calculated as the sum of the E- and Z-isomers, and not more than 15.0 per cent of the Z-isomer. Isomer-specific pharmacological activity of crotamiton is unknown.   NCATS

Chemistry

  • SMILES: C/C=C/C(=O)N(CC)c1ccccc1C
  • InChIKey: DNTGGZPQPQTDQF-XBXARRHUSA-N
  • Mol. Mass: 203.28
  • ALogP: 2.92
  • ChEMBL Molecule:
    crotamiton  
More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Alternative names

crotalgin | crotamitex | crotamiton | crotamitone | crotan | eurax | n-crotonyl-n-ethyl-o-toluidine | n-ethyl-o-crotonotoluidide | veteusan

Organizations (5)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (2)


 

Pruritus (approved 1949)

Scabies (approved 1949)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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