astemizole (Hismanal) Report issue

Small molecule Withdrawn
ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Astemizole is antihistamine drug, discovered by Janssen Pharmaceutical and used to prevent sneezing, runny nose, itching and watering of the eyes, and other allergic symptoms. The drug was withdrawn from U.S. market in 1999 due to the potential to cause arrhythmias at high doses.   NCATS

Chemistry

  • SMILES: COC1=CC=C(CCN2CCC(CC2)NC3=NC4=C(C=CC=C4)N3CC5=CC=C(F)C=C5)C=C1
  • InChIKey: GXDALQBWZGODGZ-UHFFFAOYSA-N
  • Mol. Mass: 458.5703
  • ALogP: 5.35
  • ChEMBL Molecule:
    astemizole  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Oral
  • Pro Drug: No

Alternative names

1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole | 1-(p-fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole | astemisan | astemison | astemizol | astemizole | astémizole | astemizolum | gnf-pf-2461 | hismanal | histazol | pollon-eze | r 43 512 | r-43512

Organizations (1)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (1)


 

Rhinitis, Allergic (approved 1988)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Rhinitis, Allergic, Seasonal ()

Urticaria ()

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