Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Phosphotransferases » Phosphotransferases (Alcohol Group Acceptor) » Protein Kinases » Protein-Tyrosine Kinases » Receptor Protein-Tyrosine Kinases » Proto-Oncogene Proteins c-kit
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Protein-Tyrosine Kinases » Receptor Protein-Tyrosine Kinases » Proto-Oncogene Proteins c-kit
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptor Protein-Tyrosine Kinases » Proto-Oncogene Proteins c-kit
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Immunologic » Receptors, Cytokine » Receptors, Colony-Stimulating Factor » Proto-Oncogene Proteins c-kit
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Peptide » Receptors, Growth Factor » Receptors, Colony-Stimulating Factor » Proto-Oncogene Proteins c-kit
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Oncogene Proteins » Proto-Oncogene Proteins » Proto-Oncogene Proteins c-kit
Description
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis. MeSH
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Phase 2 Indicated Drugs (2)
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