Diseases [C] » Neoplasms [C04] » Neoplastic Syndromes, Hereditary
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Neoplastic Syndromes, Hereditary
Description
The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance. MeSH
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Subtype Terms (14)
Adenomatous Polyposis Coli
37 drugs (17 approved, 20 experimental)
Basal Cell Nevus Syndrome
17 drugs (13 approved, 4 experimental)
Birt-Hogg-Dube Syndrome
2 approved drugs
Colorectal Neoplasms, Hereditary Nonpolyposis
23 drugs (17 approved, 6 experimental)
Dysplastic Nevus Syndrome
1 experimental drug
Exostoses, Multiple Hereditary
1 approved drug
Hamartoma Syndrome, Multiple
6 drugs (4 approved, 2 experimental)
Hereditary Breast and Ovarian Cancer Syndrome
10 drugs (6 approved, 4 experimental)
Li-Fraumeni Syndrome
2 approved drugs
Multiple Endocrine Neoplasia
6 drugs (5 approved, 1 experimental)
Neurofibromatoses
19 drugs (16 approved, 3 experimental)
Peutz-Jeghers Syndrome
3 approved drugs
Tuberous Sclerosis
16 drugs (11 approved, 5 experimental)
Wilms Tumor
84 drugs (50 approved, 34 experimental)
Phase 1 Indicated Drugs (2)
Organization Involved with Phase 2 Indications (1)
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UMLS Data
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