Active Ingredient History
Picosulfuric acid (as sodium picosulfate) is a contact laxative, which is used in combination with: magnesium oxide, and anhydrous citric acid for cleansing of the colon as a preparation for colonoscopy in adults. Sodium picosulfate is a prodrug. It has no significant direct physiological effect on the intestine. But it is hydrolyzed by colonic bacteria to form an active metabolite: bis-(p-hydroxy-phenyl)-pyridyl-2-methane, BHPM, which acts directly on the colonic mucosa to stimulate colonic peristalsis NCATS
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Colonoscopy (approved 2012)
Cathartics (Phase 4)
Colitis, Ulcerative (Phase 4)
Colon (Phase 4)
Colonic Diseases (Phase 4)
Colonic Neoplasms (Phase 3)
Colonic Polyps (Phase 3)
Colonoscopy (Phase 4)
Colorectal Neoplasms (Phase 4)
Constipation (Phase 3)
Drugs, Investigational (Phase 3)
Endoscopy (Phase 4)
General Surgery (Phase 4)
Glycemic Control (Phase 2)
Healthy Volunteers (Phase 2)
Inflammatory Bowel Diseases (Phase 3)
Intestinal Diseases (Phase 3)
Intestinal Neoplasms (Phase 4)
Intestine, Large (Phase 4)
Magnesium Sulfate (Phase 3)
Only Child (Phase 3)
Treatment Outcome (Phase 3)
Wounds and Injuries (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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