Active Ingredient History
Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis. It has the highest affinity for the AT1 receptor among commercially available ARBS and has minimal affinity for the AT2 receptor. New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects, as PPARγ is a nuclear receptor that regulates specific gene transcription, and whose target genes are involved in the regulation of glucose and lipid metabolism, as well as anti-inflammatory responses. This observation is currently being explored in clinical trials. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II. Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance. Telmisartan does not inhibit the angiotensin converting enzyme, other hormone receptors, or ion channels. Studies also suggest that telmisartan is a partial agonist of PPARγ, which is an established target for antidiabetic drugs. This suggests that telmisartan can improve carbohydrate and lipid metabolism, as well as control insulin resistance without causing the side effects that are associated with full PPARγ activators. Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Telmisartan is used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors). NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
---|
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
---|
Acute Coronary Syndrome (Phase 4)
Albuminuria (Phase 3)
Altitude Sickness (Phase 4)
Alzheimer Disease (Phase 2)
Aortic Aneurysm, Abdominal (Phase 4)
Atrial Fibrillation (Phase 4)
Blood Circulation (Phase 1)
Cardiovascular Diseases (Phase 4)
Cerebral Hemorrhage (Phase 3)
Cerebral Small Vessel Diseases (Phase 3)
Child (Phase 3)
Cognitive Dysfunction (Phase 3)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronavirus Infections (Phase 3)
COVID-19 (Phase 3)
Dementia, Vascular (Phase 3)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Nephropathies (Phase 4)
Dyslipidemias (Phase 4)
Endothelial Cells (Phase 2)
Essential Hypertension (Phase 4)
Glomerulonephritis, IGA (Phase 4)
Glucose Intolerance (Phase 4)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 4)
Heart Failure (Phase 4)
Hemorrhage (Phase 4)
HIV Infections (Phase 2)
Hypercholesterolemia (Phase 3)
Hyperlipidemias (Phase 3)
Hypertension ()
Hypertriglyceridemia (Phase 3)
Inflammation (Phase 4)
Insulin Resistance (Phase 2)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 4)
Kidney Transplantation (Phase 2)
Metabolic Syndrome (Phase 4)
Myocardial Infarction (Phase 4)
Neuralgia (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 4)
Obesity (Phase 4)
Polycystic Kidney Diseases (Phase 3)
Postural Balance (Phase 4)
Prostatic Neoplasms (Early Phase 1)
Proteinuria (Phase 4)
Psychotic Disorders (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Respiratory Distress Syndrome (Phase 2)
Respiratory Insufficiency (Phase 2)
SARS-CoV-2 (Phase 2/Phase 3)
Schizophrenia (Phase 4)
Schizophrenia, Treatment-Resistant (Phase 2)
Sleep Apnea, Obstructive (Early Phase 1)
Stroke (Phase 4)
Telmisartan (Phase 2)
Therapeutic Equivalency (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
---|
Feedback
Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).
Report issue