This page summarizes the full range of both experimental and approved interventions. The active ingredients in a medicine (Active Pharmaceutical Ingredients; APIs) include conventional small molecule drugs, vaccines, biologics (based upon recombinant DNA technologies), biologicals (derived from natural products), gene and cell therapies. This information includes the backgrounds of the medicines, clinical trials investigating their safety and efficacy, their intended (& approved) uses, sponsoring organizations, targets and mechanistic basis. We also compare the first FDA approval for any given drug (known as a new molecular entity; NME), from additional (secondary) NDA approvals and approvals for a generic form (known as ANDAs). Please note that since ClinicalTrials.gov is a comparatively recent dataset, the first clinical trial might occur after the approval of established medicines.
Experimental APIs
Top 5 (by most trials)
gluten (34) trifolium pratense (32) blueberry allergenic extract (19) whole wheat allergenic extract (8) viaskin peanut (7)Approved APIs
Top 5 (by most trials)
house dust mite allergen (88) timothy grass pollen allergen extract (63) birch allergen (41) short ragweed pollen allergen (30) peanut allergen (30)Unapproved APIs
Top 5 (by most trials)
NoneExperimental APIs with Trials
Top 5 (by most trials)
gluten (34) trifolium pratense (32) blueberry allergenic extract (19) whole wheat allergenic extract (8) viaskin peanut (7)Approved APIs with Trials
Top 5 (by most trials)
house dust mite allergen (88) timothy grass pollen allergen extract (63) birch allergen (41) short ragweed pollen allergen (30) peanut allergen (30)Unapproved APIs with Trials
Top 5 (by most trials)
Noneapi_id | earliest_year | trade_api_name | Active Pharmaceutical Ingredient | Clinical Trial Years | Total Trials | Max Phase | Lead Sponsors | Approval Status | API Type |
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APIs with Innovator Approval
Top 5 (by most innovator approvals)
house dust mite allergen (11) cat epidermis allergen (7) short ragweed pollen allergen (7) timothy grass pollen allergen extract (6) orchard grass pollen allergen (5)APIs with Generics Approval
Top 5 (by most generics approvals)
NoneNote: these approvals are sourced from Drugs@FDA and Purple Book, and do not currently reflect older FDA approvals and/or other evidence of US marketing.
api_id | earliest_year | trade_api_name | sponsor_org_id | Active Pharmaceutical Ingredient | Earliest NDA Sponsor | Approval Years | Innovator Approvals | Generics Approvals | Approval Status | API Type |
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