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ningetinib Report issue

Small molecule Experimental

AACT PubChem

Active Ingredient History

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Chemistry

SMILES: Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
InChIKey: VQYYQSZNRVQLIS-UHFFFAOYSA-N
Mol. Mass: 556.59
ALogP: 5.37 Partition coefficient
ChEMBL Molecule:
ningetinib

More Chemistry

Pharmacology

Mechanisms of Action:
- Hepatocyte growth factor receptor (Homo sapiens) ^UniProt
- Tyrosine-protein kinase Mer (Homo sapiens) ^UniProt
- Receptor-type tyrosine-protein kinase FLT3 (Mus musculus) ^UniProt
- Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens) ^UniProt
- Tyrosine-protein kinase receptor UFO (Homo sapiens) ^UniProt
- Vascular endothelial growth factor receptor 1 (Homo sapiens) ^UniProt
- Vascular endothelial growth factor receptor 2 (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

ningetinib

Organizations (5)

Research & Development (5)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (5)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (5)

Carcinoma, Hepatocellular (Phase 1/Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Renal Cell (Phase 1/Phase 2)

Leukemia, Myeloid, Acute (Phase 1)

Neoplasms (Phase 1)

Overview

Highest Phase: Phase 2
# of Trials: 6
# of Trial Organizations: 5

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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