curcumin Report issue

Small molecule Experimental
AACT DrugBank PubChem

Active Ingredient History

NOW
  • Now
Curcumin is a bright yellow chemical produced by plants of the Curcuma longa species. It is the principal curcuminoid of turmeric, a member of the ginger family, Zingiberaceae. It is sold as a herbal supplement, cosmetics ingredient, food flavoring, and food coloring.   Wikipedia

Chemistry

  • SMILES: COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
  • InChIKey: ZIUSSTSXXLLKKK-KOBPDPAPSA-N
  • Mol. Mass: 368.39
  • ALogP: 3.85
  • ChEMBL Molecule:
    curcumin  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

calcumin | curcuma | curcumin | curcuminoids | curcumol | diferuloylmethane | goldenseal | hydrastis | liposomal curcumin

Organizations (246)

Research & Development (246)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (140)

Approved Indications (1)


 

Neoplasms

Experimental Indications - Clinical Trial Phases 1-4 (140)


 

Acute Kidney Injury (Phase 3)

Adenocarcinoma (Phase 2)

Adenomatous Polyposis Coli (Phase 2)

Alveolar Bone Loss (Phase 4)

Alzheimer Disease (Phase 2)

Amyotrophic Lateral Sclerosis (Phase 2)

Aortic Aneurysm, Abdominal (Phase 2/Phase 3)

Arthritis, Rheumatoid (Early Phase 1)

Asthma (Phase 2)

Atherosclerosis (Phase 2)

Autonomic Nervous System Diseases (Phase 3)

Biological Availability (Phase 1/Phase 2)

Bipolar Disorder (Phase 2)

Blood Pressure (Phase 2)

Body Weight (Phase 1/Phase 2)

Breast Neoplasms (Phase 2)

Burns (Phase 1)

Cachexia (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 1/Phase 2)

Cardiovascular Abnormalities (Phase 4)

Cardiovascular Diseases (Phase 2)

Cervical Intraepithelial Neoplasia (Early Phase 1)

Cholangitis, Sclerosing (Phase 1/Phase 2)

Chronic Periodontitis (Phase 4)

Cigarette Smoking (Phase 3)

Clonal Hematopoiesis (Phase 2)

Cognition (Phase 2/Phase 3)

Cognition Disorders (Phase 2)

Cognitive Dysfunction (Phase 3)

Colitis, Ulcerative (Phase 3)

Colonic Neoplasms (Phase 3)

Colorectal Neoplasms (Phase 2)

Coronary Artery Bypass (Phase 3)

Coronavirus Infections (Phase 3)

COVID-19 (Phase 3)

Crohn Disease (Phase 3)

Dentist-Patient Relations (Phase 1)

Depression (Phase 4)

Diabetes Mellitus (Phase 2/Phase 3)

Diabetes Mellitus, Type 2 (Phase 4)

Diabetic Retinopathy (Phase 1)

Diarylheptanoids (Phase 1)

Dietary Supplements ()

Diverticulitis (Phase 2)

Drug-Related Side Effects and Adverse Reactions (Phase 3)

Dyslipidemias (Phase 2)

Endometrial Neoplasms (Phase 2)

Esophageal Neoplasms (Phase 3)

Facial Hemiatrophy (Phase 1)

Gastritis (Phase 2)

Gastrointestinal Microbiome (Phase 1/Phase 2)

Geriatrics (Phase 2/Phase 3)

Glaucoma, Open-Angle (Phase 1)

Goldenhar Syndrome (Phase 1)

Head and Neck Neoplasms (Phase 2)

Healthy Volunteers (Phase 2)

Heart Disease Risk Factors (Phase 4)

Hematoma, Subdural, Chronic (Early Phase 1)

Hemorrhage (Phase 4)

Hyperemia (Phase 2)

Hyperglycemia (Phase 3)

Hyperprolactinemia (Phase 1)

Hypertension (Phase 2)

Infections (Phase 3)

Inflammation (Phase 2)

Inflammatory Bowel Diseases (Phase 1)

Insulin Resistance (Phase 4)

Irritable Bowel Syndrome (Phase 4)

Kidney Diseases (Phase 3)

Kidney Function Tests (Phase 3)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)

Lichen Planus, Oral (Phase 2)

Lung Diseases (Phase 2)

Lung Neoplasms (Phase 3)

Lupus Erythematosus, Systemic (Phase 2)

Lymphoma (Phase 1)

Lymphoma, Primary Cutaneous Anaplastic Large Cell (Phase 2)

Lymphoma, T-Cell, Cutaneous (Phase 2)

Macular Degeneration (Phase 2)

Melanosis (Early Phase 1)

Metabolic Syndrome (Phase 2)

Metrorrhagia (Phase 4)

Migraine Disorders (Phase 4)

Monoclonal Gammopathy of Undetermined Significance (Phase 2)

Mucositis (Phase 3)

Multiple Myeloma (Phase 2)

Multiple Sclerosis (Phase 2)

Myelodysplastic Syndromes (Phase 2)

Neoplasm Metastasis (Phase 1/Phase 2)

Neoplasms (Phase 2)

Nerve Degeneration (Phase 3)

Neuralgia (Phase 3)

Neurofibromatosis 1 (Phase 1)

Non-alcoholic Fatty Liver Disease (Phase 2/Phase 3)

Optic Atrophy, Hereditary, Leber (Phase 3)

Oral Submucous Fibrosis (Phase 2)

Oral Ulcer (Early Phase 1)

Orthodontic Appliances, Fixed (Early Phase 1)

Osteoarthritis (Phase 3)

Osteoarthritis, Knee (Early Phase 1)

Osteosarcoma (Phase 1/Phase 2)

Pain (Phase 2)

Pancreatic Neoplasms (Phase 3)

Periodontitis (Phase 4)

Persian Gulf Syndrome (Phase 1/Phase 2)

Pharmacokinetics (Phase 1)

Pharmacological and Toxicological Phenomena (Phase 1)

Pharmacology (Early Phase 1)

Polycystic Kidney, Autosomal Dominant (Phase 4)

Polycythemia Vera (Phase 2)

Polymorphism, Genetic (Phase 2/Phase 3)

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Phase 2)

Prediabetic State (Phase 4)

Primary Myelofibrosis (Phase 2)

Prostatic Neoplasms (Phase 3)

Prostatic Neoplasms, Castration-Resistant (Phase 2)

Prostheses and Implants (Phase 4)

Proteinuria (Phase 3)

Psoriasis (Phase 2)

Psychotic Disorders (Phase 1/Phase 2)

Radiodermatitis (Phase 2/Phase 3)

Renal Insufficiency, Chronic (Phase 3)

Safety (Phase 1/Phase 2)

Schizophrenia (Phase 4)

Severe Acute Respiratory Syndrome (Phase 3)

Spondylitis, Ankylosing (Phase 2)

Stomach Neoplasms (Phase 3)

Stomatitis (Phase 1)

Stress Disorders, Post-Traumatic (Phase 1)

Thrombocythemia, Essential (Phase 2)

Tobacco (Phase 1/Phase 2)

Tobacco Use Disorder (Phase 2)

Urinary Bladder Diseases (Phase 1)

Urination Disorders (Phase 1)

Uterine Cervical Dysplasia (Phase 1)

Uterine Cervical Neoplasms (Phase 2)

Uterine Neoplasms (Phase 2)

Uveitis (Early Phase 1)

Vascular Stiffness (Phase 1)

Vasoconstriction (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 249
  • # of Trial Organizations: 246

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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