Active Ingredient History
Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved in cancer-related inflammation. Macrophages are known to originate from bone marrow-derived blood monocytes or yolk sac progenitors, but the exact origin of TAMs in human tumors remains to be elucidated. The composition of monocyte-derived macrophages and tissue-resident macrophages in the tumor microenvironment depends on the tumor type, stage, size, and location, thus it has been proposed that TAM identity and heterogeneity is the outcome of interactions between tumor-derived, tissue-specific, and developmental signals. Wikipedia
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Arthritis, Rheumatoid (Phase 1)
Biliary Tract Neoplasms (Phase 2)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 1)
Carcinoma, Renal Cell (Phase 1)
Giant Cell Tumor of Tendon Sheath (Phase 1/Phase 2)
Glioma (Phase 1)
Head and Neck Neoplasms (Phase 1)
Healthy Volunteers (Phase 1)
Lymphoma (Phase 1)
Lymphoma, T-Cell, Peripheral (Phase 2)
Melanoma (Phase 1)
Neoplasms (Phase 1)
Ovarian Neoplasms (Phase 1)
Pancreatic Neoplasms (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 2)
Synovitis, Pigmented Villonodular (Phase 1/Phase 2)
Triple Negative Breast Neoplasms (Phase 1/Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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