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Small molecule Experimental

AACT

Active Ingredient History

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Chemistry

SMILES: Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1
InChIKey: UEPXBTCUIIGYCY-UHFFFAOYSA-N
Mol. Mass: 502.49
ALogP: 3.93 Partition coefficient
ChEMBL Molecule:
lxh254

More Chemistry

Pharmacology

Mechanisms of Action:
- RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) ^UniProt
- Serine/threonine-protein kinase B-raf (Homo sapiens) ^UniProt
- RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) ^UniProt
- Serine/threonine-protein kinase B-raf (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

lxh254

Organizations (2)

Research & Development (2)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (5)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (5)

Carcinoma, Non-Small-Cell Lung (Phase 1)

Colorectal Neoplasms (Phase 1)

Melanoma (Phase 2)

Neoplasms (Phase 1)

Ovarian Neoplasms (Phase 1)

Overview

Highest Phase: Phase 2
# of Trials: 6
# of Trial Organizations: 2

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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