Active Ingredient History
Lifitegrast (under brand name Xiidra) was approved as an ophthalmic solution for the treatment of the signs and symptoms of dry eye disease. Lifitegrast binds to the integrin lymphocyte function-associated antigen-1 (LFA-1); a cell surface protein found on leukocytes and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). This LFA-1/ICAM-1 interaction is a key step in the inflammatory cascade that contributes to dry eye disease. Besides lifitegrast participates in phase II clinical trials for prevention of the signs and symptoms of allergic conjunctivitis. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Conjunctivitis, Allergic (Phase 2)
Contact Lenses (Phase 4)
Corneal Diseases (Phase 4)
Graft vs Host Disease (Early Phase 1)
Inflammation (Phase 4)
Keratoconjunctivitis Sicca (Phase 4)
Macular Edema (Phase 1)
Vision, Ocular (Phase 4)
Vitreous Body (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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