larotrectinib (vitrakvi) Report issue

Small molecule Orphan Drug FDA Approved FDA First in Class Accelerated Approval FDA Priority Review FDA
AACT ChEMBL Drugs@FDA MeSH PubChem

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Chemistry

Mol. Mass

428.44

ALogP

2.95

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1
  • InChIKey: NYNZQNWKBKUAII-KBXCAEBGSA-N
    InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
  • Chirality: Single Stereoisomer
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL3889654   ChEMBL
larotrectinib *

CHEMBL3545075   ChEMBL

CHEMBL3989939   ChEMBL
larotrectinib sulfate

PF9462I9HX   NCATS
larotrectinib *

Larotrectinib   Wikipedia

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