cobalamin Report issue

Small molecule Experimental
AACT Drug Central PubChem

Active Ingredient History

NOW
  • Now
Cobalamin (vitamin B12) is a cobalt-containing, B complex vitamin. B12 group (cobalamins) consist of cyanocobalamin, hydroxocobalamin, methylcobalamin and cobalamid. Neither plants nor animals are independently capable of constructing vitamin B12. Only bacteria and archaea have the enzymes required for its biosynthesis. Therefore, humans must absorb it from food. Excellent sources of B12 are foods of ruminant origin, so dairy and meat products play an important role in efforts to meet the official daily B12 intake. Vitamin B12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system. Vitamin B12 is used to treat vitamin B12 deficiency, including pernicious anemia.   NCATS

Chemistry

  • SMILES: [Co++].C[C@@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2[N-]C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@@H]6[C@@H](CO)O[C@@H]([C@@H]6O)N7C=NC8=C7C=C(C)C(C)=C8
  • InChIKey: ASARMUCNOOHMLO-WLORSUFZSA-L
  • Mol. Mass: 1329.3478
  • ALogP: Missing data
  • ChEMBL Molecule:
    cobalamin  
More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

b12 | cobalamin | cobalamine | cobalamin(iii) | menet

Organizations (90)

Research & Development (90)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (36)

Approved Indications (1)


 

Anemia, Pernicious

Experimental Indications - Clinical Trial Phases 1-4 (36)


 

Amyotrophic Lateral Sclerosis (Phase 1)

Anemia (Phase 4)

Anemia, Pernicious ()

Antioxidants (Phase 4)

Brain Injuries, Traumatic (Phase 3)

Carcinoma, Non-Small-Cell Lung (Phase 2/Phase 3)

Carcinoma, Transitional Cell (Phase 3)

Carpal Tunnel Syndrome (Phase 1)

Coronavirus Infections (Phase 3)

COVID-19 (Phase 3)

Diabetes Mellitus (Phase 4)

Drug-Related Side Effects and Adverse Reactions (Phase 2/Phase 3)

Infertility, Male (Phase 4)

Ischemic Stroke (Phase 2/Phase 3)

Kidney Failure, Chronic (Phase 3)

Lung Neoplasms (Phase 2/Phase 3)

Lymphoma, Large-Cell, Immunoblastic (Phase 2/Phase 3)

Lymphoma, T-Cell (Phase 3)

Malnutrition (Early Phase 1)

Neoplasm Metastasis (Phase 1/Phase 2)

Neoplasms (Phase 4)

Obesity (Phase 4)

Oxidative Stress (Phase 2/Phase 3)

Pharmacology (Phase 2/Phase 3)

Pregnancy Complications (Phase 4)

Premature Ejaculation (Phase 3)

Psychotic Disorders (Phase 3)

Schizophrenia (Phase 4)

Semen Analysis (Phase 4)

Stomach Neoplasms (Early Phase 1)

Stomatitis (Phase 2)

Stress Disorders, Post-Traumatic (Phase 1)

Stroke (Phase 1)

Ureteral Neoplasms (Phase 3)

Urinary Bladder Neoplasms (Phase 3)

Vitamin B 12 Deficiency (Phase 2/Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 52
  • # of Trial Organizations: 90

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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