Active Ingredient History
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied. Used for the treatment and management of chronic alcoholism. NCATS
Drug Pricing (per unit)
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Alcoholism (approved 1981)
Alcohol-Induced Disorders (Phase 1/Phase 2)
Alcoholism ()
Alcohol-Related Disorders (Phase 2)
Analgesics, Opioid (Phase 2)
Anxiety Disorders (Phase 4)
Breast Neoplasms (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2/Phase 3)
Cocaine-Related Disorders (Phase 4)
COVID-19 (Phase 2)
Fatigue (Phase 1/Phase 2)
Glioblastoma (Phase 2/Phase 3)
Glioma (Phase 2/Phase 3)
HIV (Phase 1/Phase 2)
HIV Infections (Phase 1/Phase 2)
Hyperhidrosis (Phase 2)
Machiavellianism (Phase 1)
Macular Degeneration (Phase 1/Phase 2)
Melanoma (Phase 2)
Methamphetamine (Phase 1/Phase 2)
Multiple Myeloma (Phase 1)
Neoplasms (Phase 1)
Neoplasms, Germ Cell and Embryonal (Phase 2)
Obesity (Early Phase 1)
Opioid-Related Disorders (Phase 2)
Pancreatic Neoplasms (Phase 2)
Prostatic Neoplasms (Phase 1)
Quality of Life (Phase 1/Phase 2)
Retina (Phase 1/Phase 2)
Sarcoma (Phase 1)
Substance-Related Disorders (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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