sotorasib (LUMAKRAS) Report issue

Small molecule Orphan Drug FDA Approved FDA First in Class Fast Track FDA Breakthrough Therapy FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

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Chemistry

  • SMILES: C=CC(=O)N1CCN(c2nc(=O)n(-c3c(C)ccnc3C(C)C)c3nc(-c4c(O)cccc4F)c(F)cc23)[C@@H](C)C1
  • InChIKey: NXQKSXLFSAEQCZ-SFHVURJKSA-N
  • Mol. Mass: 560.61
  • ALogP: 4.48
  • ChEMBL Molecule:
    sotorasib  
More Chemistry

Pharmacology

Organizations (40)

Research & Development (40)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (19)

Approved Indications (1)


 

Carcinoma, Non-Small-Cell Lung (approved 2021)

Experimental Indications - Clinical Trial Phases 1-4 (19)


 

Adenocarcinoma of Lung (Phase 2)

Breast Neoplasms (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 3)

Colorectal Neoplasms (Phase 3)

Drug Evaluation (Phase 2)

Endometrial Neoplasms (Phase 2)

Fallopian Tube Neoplasms (Phase 2)

Hamartoma (Phase 2)

Healthy Volunteers (Phase 1)

Liver Diseases (Phase 1)

Lung Neoplasms (Phase 2)

Mutation (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasms (Phase 2)

Ovarian Neoplasms (Phase 2)

Pancreatic Neoplasms (Phase 1/Phase 2)

Proto-Oncogene Proteins p21(ras) (Phase 2)

ras Proteins (Phase 2)

Small Cell Lung Carcinoma (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 45
  • # of Trial Organizations: 40

Trials by Phase

Trial Phase Start Date Organizations Indications

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