pyronaridine Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central MeSH PubChem

Active Ingredient History

NOW
  • Now
Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s.   Wikipedia

Chemistry

  • SMILES: COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1
  • InChIKey: DJUFPMUQJKWIJB-UHFFFAOYSA-N
  • Mol. Mass: 518.06
  • ALogP: 6.09
  • ChEMBL Molecules:
    pyronaridine  
    pyronaridine tetraphosphate  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

2-methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine | 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol | 4-((7-chloro-2-methoxybenzo(b)(1,5)naphthyridin-10-yl)amino)-2,6-bis((pyrrolidin-1-yl)methyl)phenol | benzonaphthyridine 7351 | malaridine | phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)- | phenol, 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)-, phosphate (1:4) | pyonaridine | pyronaridine | pyronaridine phosphate salt | pyronaridine tetraphosphate

Organizations (42)

Research & Development (42)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (11)

Approved Indications (1)


 

Malaria

Experimental Indications - Clinical Trial Phases 1-4 (11)


 

COVID-19 (Phase 3)

Healthy Volunteers (Phase 1)

Leukemia, Myeloid, Acute (Phase 2)

Malaria (Phase 3)

Malaria, Falciparum (Phase 4)

Parasitemia (Phase 1)

Parasitic Diseases (Phase 1)

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Phase 2)

Pregnancy Complications (Phase 3)

Protozoan Infections (Phase 1)

Schistosomiasis haematobia (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 35
  • # of Trial Organizations: 42

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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