estrone Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase. It’s used as hameopatic in management of premenopausal and postmenopausal symptoms. In 1929, Butenandt isolated estrone from the urine of pregnant women. Estrone is known to be a carcinogen for human females as well as a cause of breast tenderness or pain, nausea, headache, hypertension, and leg cramps in the context of non-endogenous exposure. In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile dysfunction. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol.   NCATS

Chemistry

  • SMILES: Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2
  • InChIKey: PHWXUGHIIBDVKD-UHFFFAOYSA-N
  • Mol. Mass: 454.91
  • ALogP: 3.96
  • ChEMBL Molecules:
    sitaxentan  
    estrone  
    sitaxentan sodium  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Alternative names

3-hydroxy-1,3,5(10)-estratrien-17-one | e1 | estrogenic substance | estron | estrona | estrone | estronum | estrugenone | follicular hormone | folliculin | oestrin | oestrone | theelin | thelin

Organizations (8)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (14)

Approved Indications (2)


 

Endometrial Hyperplasia

Menopause

Experimental Indications - Clinical Trial Phases 1-4 (12)


 

Amenorrhea ()

Breast Diseases ()

Breast Neoplasms ()

Diabetes Mellitus, Type 1 (Phase 1)

Diabetes Mellitus, Type 2 (Phase 1)

Endometrial Neoplasms ()

Infertility ()

Obesity ()

Ovarian Diseases ()

Premenstrual Syndrome (Phase 3)

Prostatic Neoplasms ()

Puberty, Precocious ()

Overview

  • Highest Phase: Phase 1
  • # of Trials: 3
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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