dipivefrin (propine) Report issue

Small molecule Approved FDA Priority Review FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating α -and/or β2-adrenergic receptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy. Dipivefrin is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.   NCATS

Chemistry

  • SMILES: CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1
  • InChIKey: OCUJLLGVOUDECM-UHFFFAOYSA-N
  • Mol. Mass: 351.44
  • ALogP: 2.84
  • ChEMBL Molecules:
    dipivefrin  
    dipivefrin hydrochloride  
More Chemistry

Pharmacology

Alternative names

1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol | (+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate | 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate | adrenaline dipivalate | akpro | alcon brand of dipivefrin hydrochloride | allergan brand of dipivefrin hydrochloride | apo-dipivefrin | apotex brand of dipivefrin hydrochloride | d epifrin | diopine | dipivaloylepinephrine | dipivalyl epinephrine | dipivefrin | dipivefrina | dipivefrin acetate, (+-)-isomer | dipivefrin citrate (1:1), (+-)-isomer | dipivefrine | dipivéfrine | dipivefrine hydrochloride | dipivefrin hcl | dipivefrin hydrochloride | dipivefrin hydrochloride, (+-)-isomer | dipivefrin monophosphate, (+-)-isomer | dipivefrin monosulfate, (+-)-isomer | dipivefrin nitrate, (+-)-isomer | dipivefrin perchlorate | dipivefrin propanoate, (+-)-isomer | dipivefrin, (r)-isomer | dipivefrin tartrate (1:1), (+-)-(r-(r*,r*))-isomer | dipivefrin tartrate (1:1), (r)-(r-(r*,r*))-isomer | dipivefrinum | dipoquin | dpe | glaucothil | glaudrops | ioquin brand of dipivefrin hydrochloride | pharm-allergan brand of dipivefrin hydrochloride | pharmascience brand of dipivefrin hydrochloride | pms-dipivefrin | pro-epinephrine | propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, (+-)- | propine | ratio-dipivefrin | ratiopharm brand of dipivefrin hydrochloride

Organizations (5)

Research & Development (0)

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Marketing (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (2)


 

Glaucoma, Open-Angle (approved 1980)

Ocular Hypertension

Experimental Indications - Clinical Trial Phases 1-4 (0)

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