API | lucanthone

lucanthone Report issue

Small molecule Experimental

AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW

Lucanthone is a thioxanthenone DNA intercalator. It inhibits topoisomerases and the dual function base excision repair enzyme apurinic endonuclease 1. Lucanthone has been devised for the treatment of schistosomiasis. It is also an antitumor agent. Lucanthone was being developed by Spectrum Pharmaceuticals for the treatment of malignant brain tumours. ^NCATS

Chemistry

SMILES: CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12
InChIKey: FBQPGGIHOFZRGH-UHFFFAOYSA-N
Mol. Mass: 340.49
ALogP: 4.48 Partition coefficient
ChEMBL Molecules:

lucanthone

lucanthone hydrochloride

More Chemistry

Pharmacology

Mechanism of Action:
- Vacuolar aminopeptidase 1 (Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

1-((2-(diethylamino)ethyl)amino)-4-methylthioxanthen-9-one | 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one | 1-diethylaminoethylethylamino-4-methyl-thioxanthenone | 79 t61 | lucanthone | lucanthone hcl | lucanthone hydrochloride | lucanthonum | lucantona | miracil

Organizations (10)

Research & Development (10)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (3)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (3)

Brain Neoplasms (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Glioblastoma (Phase 2)

Overview

Highest Phase: Phase 2
# of Trials: 2
# of Trial Organizations: 10

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue