dihydroergocristine mesylate Report issue

Small molecule Experimental
ChEMBL Drug Central KEGG MeSH PubChem

Active Ingredient History

Dihydroergocristine is an ergot alkaloid that has an partial agonist activity on dopaminergic and alpha-adrenergic receptors and antagonist activity on serotonin receptors. The drug was approved by FDA in combination with other alkaloids (dihydroergocornine, dihydro-alpha-ergocryptine and dihydro-beta-ergocryptine mesylate salts) under the name Hydergine for the treatment of dimentia and cerebrovascular insufficiency.   NCATS

Chemistry

  • SMILES: CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
  • InChIKey: DEQITUUQPICUMR-HJPBWRTMSA-N
  • Mol. Mass: 611.74
  • ALogP: 2.72
  • ChEMBL Molecules:
    dihydroergocristine  
    dihydroergocristine mesylate  
More Chemistry

Pharmacology

Alternative names

9,10-dihydroergocristine | dihydroergocristin | dihydroergocristine | dihydroergocristine mesilate | dihydroergocristine mesylate | gnf-pf-3462

Indications (2)

Approved Indications (2)


 

Cerebrovascular Disorders (approved 1977)

Dementia (approved 1977)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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