National Institute of Mental Health (NIMH)   Report issue

Government Phase 1 Phase 2 Phase 3 Phase 4
Founded: Bethesda MD United States (1949)

Organization Overview

First Clinical Trial
1986
NCT00693212
First Marketed Drug
None
First NDA Approval
None
Last Known Activity
2023

Timeline

NOW
  • Now

Alternative names

Joseph Blader | National Institute of Mental Health (NIMH) | National Institute on Mental Health

Active Ingredients

Drugs in Phase 4 Trials (111)

11c dasb (1 trial)

aldesleukin (Proleukin) (1 trial)

alendronic acid (fosamax) (1 trial)

alprazolam (2 trials)

amphetamine (Adderall) (5 trials)

aripiprazole (abilify) (17 trials)

armodafinil (nuvigil) (1 trial)

asenapine (saphris) (1 trial)

atazanavir (reyataz) (1 trial)

atomoxetine (strattera) (8 trials)

benzatropine (cogentin) (1 trial)

bictegravir (Biktarvy) (1 trial)

buprenorphine (2 trials)

bupropion (wellbutrin) (18 trials)

buspirone (buspar) (1 trial)

cabotegravir (Vocabria) (3 trials)

calcium carbonate (1 trial)

carbidopa (sinemet) (6 trials)

chlorpromazine (Thorazine) (1 trial)

citalopram (celexa) (32 trials)

clonazepam (klonopin) (3 trials)

clozapine (clozaril) (13 trials)

cobalamin (1 trial)

cobicistat (stribild) (1 trial)

cycloserine (seromycin) (14 trials)

darunavir (prezista) (1 trial)

desipramine (pertofrane) (3 trials)

desvenlafaxine (pristiq) (1 trial)

dolutegravir (tivicay) (3 trials)

donepezil (aricept) (9 trials)

doravirine (pifeltro) (1 trial)

dronabinol (marinol) (2 trials)

drospirenone (Yasmin) (2 trials)

d-serine (4 trials)

duloxetine (Cymbalta) (4 trials)

efavirenz (sustiva) (1 trial)

emtricitabine (emtriva) (7 trials)

escitalopram (lexapro) (41 trials)

estradiol (progynon depot) (18 trials)

estrogen (2 trials)

eszopiclone (lunesta) (2 trials)

ethinyl estradiol (Estinyl) (2 trials)

fluoxetine (prozac) (36 trials)

fluphenazine (permitil) (1 trial)

flutamide (eulexin) (1 trial)

folic acid (2 trials)

galantamine (reminyl) (5 trials)

guanfacine (tenex) (4 trials)

haloperidol (haldol) (4 trials)

hepatitis a vaccine, inactivated (vaqta) (2 trials)

hepatitis b vaccine (recombinant) (Recombivax) (3 trials)

ibuprofen (motrin) (1 trial)

iloperidone (fanapt) (1 trial)

infliximab (remicade) (3 trials)

isoflavone (2 trials)

ketamine (ketalar) (28 trials)

lamivudine (epivir) (3 trials)

lamotrigine (lamictal) (9 trials)

levodopa (larodopa) (7 trials)

liothyronine (cytomel) (2 trials)

lisdexamfetamine (vyvanse) (2 trials)

lithium (lithonate) (28 trials)

lopinavir (Kaletra) (2 trials)

lorazepam (ativan) (5 trials)

lovastatin (mevacor) (1 trial)

lurasidone (latuda) (1 trial)

maprotiline (ludiomil) (3 trials)

memantine (namenda) (3 trials)

methylphenidate (ritalin) (25 trials)

midazolam (versed) (6 trials)

minocycline (minocin) (4 trials)

mirtazapine (remeron) (7 trials)

modafinil (provigil) (4 trials)

molindone (moban) (1 trial)

nevirapine (viramune) (3 trials)

nimodipine (nimotop) (1 trial)

nortriptyline (aventyl) (8 trials)

olanzapine (zyprexa) (28 trials)

oxytocin (syntocinon) (10 trials)

paliperidone (invega) (4 trials)

paroxetine (paxil) (18 trials)

perphenazine (trilafon) (4 trials)

pimozide (orap) (1 trial)

pioglitazone (actos) (1 trial)

pramipexole (mirapex) (5 trials)

pregabalin (lyrica) (1 trial)

procaine benzylpenicillin (novocaine) (3 trials)

progesterone (progestasert) (12 trials)

propranolol (inderal) (5 trials)

quetiapine (seroquel) (13 trials)

raclopride (2 trials)

raloxifene (evista) (1 trial)

riluzole (rilutek) (7 trials)

risperidone (risperdal) (37 trials)

ritonavir (Norvir) (2 trials)

sertraline (zoloft) (51 trials)

simvastatin (zocor) (1 trial)

sitagliptin (januvia) (5 trials)

sodium chloride (4 trials)

suvorexant (belsomra) (1 trial)

tenofovir (viread) (18 trials)

tenofovir alafenamide (genvoya) (1 trial)

tranylcypromine (parnate) (3 trials)

trazodone (desyrel) (3 trials)

valproic acid (depakene) (17 trials)

varenicline (chantix) (1 trial)

venlafaxine (effexor) (22 trials)

yinhsing (1 trial)

zidovudine (retrovir) (2 trials)

ziprasidone (geodon) (8 trials)

zolpidem (ambien) (6 trials)

Drugs in Phase 3 Trials (15)

aciclovir (zovirax) (1 trial)

celecoxib (celebrex) (3 trials)

clomipramine (anafranil) (1 trial)

erythromycin (ilosone) (2 trials)

fish oil (Omegavan) (3 trials)

fluvoxamine (luvox) (3 trials)

glycine (3 trials)

icosapent ethyl (vascepa) (11 trials)

immune globulin (human) (Gamastan) (2 trials)

metronidazole (flagyl) (1 trial)

naltrexone (revia) (3 trials)

omega-3 fatty acids (Omacor) (1 trial)

tropisetron (1 trial)

tryptophan (1 trial)

verapamil (calan) (1 trial)

Drugs in Phase 2 Trials (63)

11c-emo (1 trial)

abacavir (ziagen) (1 trial)

amino acids (Freamine) (2 trials)

azd-2327 (1 trial)

bacille calmette-guerin (1 trial)

baricitinib (olumiant) (2 trials)

brexanolone (Zulresso) (1 trial)

btrx-246040 (1 trial)

ceftriaxone (rocephin) (1 trial)

cerc-501 (1 trial)

citicoline (1 trial)

dar-100a (1 trial)

dehydroepiandrosterone (1 trial)

diazoxide (hyperstat) (1 trial)

ethanol (1 trial)

ezogabine (potiga) (1 trial)

fallypride (1 trial)

farampator (1 trial)

felbamate (Felbatol) (1 trial)

fluconazole (diflucan) (1 trial)

gabapentin (neurontin) (2 trials)

gts-21 (2 trials)

hepatitis-a virus (inactivated) / hepatitis-b surface antigen (twinrix) (1 trial)

l-4-cl-kyn (1 trial)

lanicemine (2 trials)

leuprolide (lupron) (5 trials)

levetiracetam (keppra) (1 trial)

lobeline (1 trial)

mecasermin (Increlex) (1 trial)

medroxyprogesterone (provera) (1 trial)

melatonin (1 trial)

meppep (1 trial)

methylene blue (proveblue) (1 trial)

mifepristone (mifeprex) (1 trial)

nabilone (cesamet) (1 trial)

nicotine (nicorette) (5 trials)

nitrous oxide (2 trials)

pbr28 (7 trials)

pentoxifylline (trental) (1 trial)

peptide t (3 trials)

phytoestrogens (1 trial)

pregnenolone (1 trial)

ps13 (3 trials)

psilocybin (1 trial)

rilpivirine (edurant) (2 trials)

roflumilast (daliresp) (1 trial)

Rolipram (4 trials)

s-adenosyl methionine (1 trial)

scopolamine (transderm scop) (2 trials)

succimer (Chemet) (1 trial)

tamoxifen (nolvadex) (1 trial)

testosterone (delatestryl) (1 trial)

tolcapone (tasmar) (1 trial)

ts-161 (1 trial)

ubiquinone (2 trials)

ucb-j (1 trial)

ulipristal (ella) (1 trial)

uridine (2 trials)

vasopressin (vasostrict) (3 trials)

vofopitant (1 trial)

volinanserin (1 trial)

xen1101 (1 trial)

yohimbine (1 trial)

Drugs in Phase 1 Trials (46)

11c-er176 (1 trial)

11c-meppep (1 trial)

[(11)c](-)-rway (1 trial)

11c-yjh08 (1 trial)

18f fbr (1 trial)

18f fmpep-d2 (1 trial)

18f-pf-06445974 (1 trial)

(2-fluoromethoxy-5-(5-trifluoromethyltetrazol-1-yl)benzyl)(2-phenylpiperidin-3-yl)amine (1 trial)

(2r,6r)-hydroxynorketamine hydrochloride (1 trial)

anvylic-3288 (2 trials)

aprepitant (Emend) (2 trials)

bedaquiline (sirturo) (1 trial)

betahistine mesilate (1 trial)

bpn14770 (1 trial)

cerc-301 (1 trial)

cyclophosphamide (cytoxan) (1 trial)

dapivirine (1 trial)

dexmedetomidine (precedex) (1 trial)

dutasteride (avodart) (1 trial)

emapunil (1 trial)

endotoxin (1 trial)

er-176 (1 trial)

glucocerebrosidase (lysodase) (1 trial)

hydrocortisone (solu-cortef) (1 trial)

hydroxyethyl starch (voluven) (1 trial)

leucine (1 trial)

levonorgestrel (1 trial)

lipopolysaccharide (1 trial)

ly2428703 (1 trial)

mes-impy (1 trial)

nitrofurantoin (furadantin) (1 trial)

nnc-112 (1 trial)

nop-1a (1 trial)

perampanel (fycompa) (2 trials)

pittsburgh compound b (1 trial)

pomaglumetad (2 trials)

pretomanid (1 trial)

propofol (diprivan) (1 trial)

sf12051 (1 trial)

sp203 (1 trial)

srx-246 (2 trials)

stx107 (1 trial)

telmisartan (micardis) (1 trial)

ts-134 (1 trial)

typhoid vi polysaccharide vaccine (Typhim Vi) (2 trials)

vcp1521 (1 trial)

Drugs in Other Trials (21)

amisulpride (BARHEMSYS) (2 trials)

autologous microbiome (1 trial)

baclofen (lioresal) (1 trial)

calcium (1 trial)

cortisone acetate (cortone) (1 trial)

escalitopram (Lexapro) (1 trial)

glucose (1 trial)

hypericum perforatum (2 trials)

imipramine (tofranil) (1 trial)

isoprenaline (1 trial)

myoinositol (1 trial)

ondansetron (zofran) (1 trial)

orlistat (xenical) (1 trial)

prazosin (minipress) (1 trial)

raltegravir (isentress) (1 trial)

sodium oxybate (xyrem) (1 trial)

somatorelin (1 trial)

urea (3 trials)

vitamin d3 (4 trials)

xr-mas (1 trial)

zinc dichloride (1 trial)

Indications

Experimental Indications (Clinical Trials, Phases 1-4)


 

Abdominal Pain (Phase 3)

Acquired Immunodeficiency Syndrome (Phase 3)

Aggression (Phase 4)

Agoraphobia (Phase 3)

Alcoholism (Phase 2)

Alzheimer Disease (Phase 4)

Anhedonia (Phase 2)

Anorexia (Phase 4)

Anorexia Nervosa (Phase 4)

Anxiety Disorders (Phase 4)

Anxiety, Separation (Phase 3)

Asperger Syndrome (Phase 2)

Asphyxia Neonatorum (Phase 4)

Atherosclerosis (Phase 1)

Attention Deficit and Disruptive Behavior Disorders (Phase 4)

Attention Deficit Disorder with Hyperactivity (Phase 4)

Autism Spectrum Disorder (Phase 4)

Autistic Disorder (Phase 4)

Autoimmune Diseases (Phase 4)

Behavioral Symptoms (Phase 4)

Binge-Eating Disorder (Phase 2)

Bipolar Disorder (Phase 4)

Body Dysmorphic Disorders (Phase 3)

Bone Diseases, Metabolic (Phase 4)

Borderline Personality Disorder (Phase 4)

Bulimia (Phase 2)

Bulimia Nervosa (Phase 2)

Cardiovascular Diseases (Phase 2)

Carotid Artery Diseases (Phase 1)

Central Nervous System Diseases (Phase 4)

Child Development Disorders, Pervasive (Phase 4)

Chorioamnionitis (Phase 3)

Chromosome Deletion (Phase 2)

Chromosome Disorders (Phase 2)

Cognition Disorders (Phase 4)

Cognitive Dysfunction (Phase 4)

Communicable Diseases (Phase 4)

Compulsive Personality Disorder (Phase 4)

Conduct Disorder (Phase 4)

Coronary Artery Disease (Phase 2)

Coronary Disease (Phase 2)

Cysticercosis (Phase 1)

Delusions (Phase 4)

Dementia (Phase 4)

Dementia, Vascular (Phase 3)

Depression (Phase 4)

Depression, Postpartum (Phase 4)

Depressive Disorder (Phase 4)

Depressive Disorder, Major (Phase 4)

Depressive Disorder, Treatment-Resistant (Phase 4)

Developmental Disabilities (Phase 4)

Diabetes Mellitus (Phase 4)

Disease (Phase 4)

Disruptive, Impulse Control, and Conduct Disorders (Phase 2)

Dyskinesia, Drug-Induced (Phase 1)

Dyskinesias (Phase 1)

Dysthymic Disorder (Phase 4)

Epilepsy (Phase 4)

Fatigue (Phase 4)

Feeding and Eating Disorders (Phase 4)

Fragile X Syndrome (Phase 2)

Frailty (Phase 4)

Gambling (Phase 3)

Gaucher Disease (Phase 1)

Head and Neck Neoplasms (Phase 4)

Heart Diseases (Phase 2)

Heart Failure (Phase 3)

Hepatitis (Phase 4)

Hepatitis A (Phase 4)

Hepatitis B (Phase 4)

Hepatitis B, Chronic (Phase 2)

Herpes Genitalis (Phase 3)

HIV Infections (Phase 4)

HIV Seropositivity (Phase 4)

Hot Flashes (Phase 4)

Hyperkinesis (Phase 4)

Hypochondriasis (Phase 2)

Infections (Phase 4)

Inflammation (Phase 4)

Insulin Resistance (Phase 4)

Malnutrition (Phase 4)

Memory Disorders (Phase 4)

Mental Disorders (Phase 4)

Metabolic Syndrome (Phase 4)

Mood Disorders (Phase 4)

Movement Disorders (Phase 1)

Musculoskeletal Pain (Phase 4)

Myocardial Ischemia (Phase 2)

Myositis (Phase 1)

Nervous System Diseases (Phase 4)

Neurocognitive Disorders (Phase 2)

Neurocysticercosis (Phase 1)

Neurodegenerative Diseases (Phase 1)

Neurodevelopmental Disorders (Phase 3)

Obsessive-Compulsive Disorder (Phase 4)

Osteoporosis (Phase 4)

Panic Disorder (Phase 4)

Parkinson Disease (Phase 4)

Personality Disorders (Phase 4)

Phobia, Social (Phase 4)

Phobic Disorders (Phase 4)

Premenstrual Dysphoric Disorder (Phase 4)

Premenstrual Syndrome (Phase 4)

Problem Behavior (Phase 3)

Psychomotor Agitation (Phase 4)

Psychotic Disorders (Phase 4)

Recurrence (Phase 4)

Schizophrenia (Phase 4)

Schizophrenia, Childhood (Phase 4)

Schizophrenia, Paranoid (Phase 4)

Schizophrenia Spectrum and Other Psychotic Disorders (Phase 4)

Schizotypal Personality Disorder (Phase 4)

Seasonal Affective Disorder (Phase 2)

Self Mutilation (Phase 4)

Sleep Initiation and Maintenance Disorders (Phase 4)

Sleep Wake Disorders (Phase 4)

Somatoform Disorders (Phase 3)

Streptococcal Infections (Phase 4)

Stress Disorders, Post-Traumatic (Phase 4)

Stress Disorders, Traumatic (Phase 4)

Stress Disorders, Traumatic, Acute (Phase 4)

Stroke (Phase 4)

Substance-Related Disorders (Phase 3)

Suicidal Ideation (Phase 4)

Suicide (Phase 4)

Suicide, Attempted (Phase 4)

Syndrome (Phase 4)

Taeniasis (Phase 1)

Tic Disorders (Phase 4)

Tics (Phase 4)

Tourette Syndrome (Phase 4)

Tuberculosis (Phase 4)

Weight Gain (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 615
  • # of Trial APIs: 256