Organization | Smith & Nephew

Smith & Nephew Report issue

Contributed to NME For profit Phase 1 Phase 2 Phase 3 Phase 4

Founded: Kingston upon Hull United Kingdom (1856)

Status: No NME R&D (1856)

Organization Overview

First Clinical Trial

2012

NCT01656889

First Marketed Drug

1965

collagenase clostridium histolyticum (xiaflex)

First NDA Approval

1997

becaplermin (regranex)

Last Known Activity

2021

Timeline

NOW

Mergers & Acquisitions

Historical Acquisition Tree

Alternative names

SMITH AND NEPHEW | Smith and Nephew Biotherapeutics | Smith & Nephew Biotherapeutics; Chief Medical Officer | Smith & Nephew, Inc.

Active Ingredients

Marketed Drugs (21)

Key: Smith & Nephew (20) Acquired (1)

aminophylline (aminophyllin)

becaplermin (regranex) (1997 NDA)

collagenase clostridium histolyticum (xiaflex) (1965)

dopamine (intropin)

droperidol (innovar) (1988)

fluorouracil (efudex)

furosemide (lasix)

haloperidol (haldol)

heparin (liquaemin)

hydralazine (apresoline)

hydroxyzine (vistaril)

methyldopa (aldomet)

metoclopramide (reglan) (1987)

naloxone (narcan)

nitroglycerin (transderm-nitro) (1986)

phenytoin (mesantoin)

procainamide (pronestyl)

prochlorperazine (compazine)

propranolol (inderal)

trimethobenzamide (tigan)

verapamil (calan)

Drugs in Phase 4 Trials (8)

Key: Smith & Nephew (1) Acquired (7)

aluminum hydroxide (Gaviscon) (1 trial)

bacitracin (polysporin) (4 trials)

collagenase clostridium histolyticum (xiaflex) (14 trials)

colloidal silver (1 trial)

human placenta hydrolysate (2 trials)

lidocaine (xylocaine) (1 trial)

petrolatum, white (Vaseline) (3 trials)

ropivacaine (naropin) (2 trials)

Drugs in Phase 3 Trials (4)

Key: Smith & Nephew (0) Acquired (4)

autologous mesenchymal stem cells (2 trials)

bone marrow derived mesenchymal stem cells (2 trials)

cham (1 trial)

hp802-247 (8 trials)

Drugs in Phase 2 Trials (5)

Key: Smith & Nephew (0) Acquired (5)

castor oil (6 trials)

hp828-101 (2 trials)

hyaluronic acid (1 trial)

myroxylon balsamum (6 trials)

trypsin (6 trials)

Drugs in Phase 1 Trials (1)

Key: Smith & Nephew (0) Acquired (1)

human fibrin (Tisseel) (1 trial)

Indications

Experimental Indications (Clinical Trials, Phases 1-4)

Diabetic Foot (Phase 4)

Foot Ulcer (Phase 4)

Leg Ulcer (Phase 3)

Pressure Ulcer (Phase 4)

Ulcer (Phase 4)

Varicose Ulcer (Phase 3)

Overview

Highest Phase: Phase 4
# of Trials: 40
# of Trial APIs: 18