Organization | Schering-Plough

Schering-Plough Report issue

Contributed to NME For profit Phase 1 Phase 2 Phase 3 Phase 4

Founded: Kenilworth NJ United States (1971)

Status: Acquired by Merck (2009)

Organization Overview

First Clinical Trial

1996

NCT01404936

First Marketed Drug

1971

estradiol (progynon depot)

First NDA Approval

1977

azatadine (optimine)

Last Known Activity

2012

Timeline

NOW

Mergers & Acquisitions

Historical Acquisition Tree

Alternative names

PT. Schering-Plough. Tbk Indonesia | SCHERING PLOUGH | Subsidiary of Schering-Plough

Active Ingredients

Marketed Drugs (43)

Key: Schering-Plough (40) Acquired (3)

acetaminophen (tylenol) (1987)

acrisorcin (akrinol) (1964 NDA)

albuterol (proventil) (1981 NDA)

anisindione (NDA)

avobenzone (shade uvaguard) (NDA)

azatadine (optimine) (1977 NDA)

beclomethasone (vanceril) (1976)

betamethasone (celestone) (1961 NDA)

desloratadine (clarinex) (2001 NDA)

dexbrompheniramine (disomer) (1959 NDA)

dexchlorpheniramine maleate (polaramine) (1959 NDA)

diazoxide (hyperstat) (1973)

diphemanil methylsulfate (prantal) (1976)

estradiol (progynon depot) (1933 NDA)

ethinyl estradiol (Estinyl) (1943 NDA)

ezetimibe (zetia) (2002)

fluphenazine (permitil) (1959 NDA)

flutamide (eulexin) (1989)

gentamicin (garamycin) (1979)

guanidine (1939 NDA)

halazepam (paxipam) (1981 NDA)

hydrochlorothiazide (esidrix) (1987)

interferon alpha-2b (Intron-A) (2008)

isosorbide (isordil) (1993)

labetalol (trandate) (NDA)

loratadine (claritin) (NDA)

methyltestosterone (testred) (1979)

metoclopramide (reglan) (1987)

mometasone (elocon) (1987 NDA)

netilmicin (netromycin) (1983)

oxymetazoline (ocuclear) (1986 NDA)

perphenazine (trilafon) (1957 NDA)

polymyxin b sulfate (poly-rx) (1981)

posaconazole (noxafil) (2006 NDA)

potassium chloride (klor-con) (1986)

prednisolone (hydeltra) (1978)

prednisone (meticorten) (1955 NDA)

propranolol (inderal) (1985)

pseudoephedrine (Benylin) (1963 NDA)

ribavirin (virazole) (2003)

temozolomide (temodar) (1999 NDA)

theophylline (synophylate) (1979)

urea (1975)

Drugs in Phase 4 Trials (38)

Key: Schering-Plough (26) Acquired (12)

acarbose (precose) (1 trial)

adalimumab (humira) (1 trial)

amlodipine (norvasc) (1 trial)

asenapine (saphris) (1 trial)

atorvastatin (lipitor) (4 trials)

azathioprine (imuran) (2 trials)

budesonide (rhinocort) (1 trial)

buprenorphine (2 trials)

colchicine (colbenemid) (1 trial)

desogestrel (Mercilon) (3 trials)

doxorubicin (Doxil) (8 trials)

epoetin (Epogen) (1 trial)

eptifibatide (integrilin) (3 trials)

estradiol (progynon depot) (2 trials)

ethinyl estradiol (Estinyl) (3 trials)

ezetimibe (zetia) (11 trials)

fluticasone (cutivate) (2 trials)

ganirelix (1 trial)

indapamide (lozol) (1 trial)

infliximab (remicade) (7 trials)

interferon alpha-2b (Intron-A) (35 trials)

leuprolide (lupron) (2 trials)

medroxyprogesterone (provera) (1 trial)

methadone (methadose) (1 trial)

methylprednisolone (medrol) (1 trial)

mometasone (elocon) (9 trials)

norelgestromin (Evra) (1 trial)

norgestimate (1 trial)

olmesartan (benicar) (1 trial)

paroxetine (paxil) (1 trial)

perindopril (aceon) (1 trial)

pioglitazone (actos) (1 trial)

posaconazole (noxafil) (4 trials)

ribavirin (virazole) (12 trials)

sargramostim (leukine) (4 trials)

simvastatin (zocor) (6 trials)

sitagliptin (januvia) (1 trial)

tibolone (xyvion) (1 trial)

Drugs in Phase 3 Trials (29)

Key: Schering-Plough (24) Acquired (5)

allopurinol (zyloprim) (1 trial)

amantadine (symmetrel) (1 trial)

amifostine (ethyol) (1 trial)

bleomycin (blenoxane) (2 trials)

carboplatin (paraplatin) (2 trials)

citalopram (celexa) (1 trial)

cyclophosphamide (cytoxan) (3 trials)

cytarabine (cytosar-u) (3 trials)

dutasteride (avodart) (1 trial)

enoxaparin (lovenox) (1 trial)

fluconazole (diflucan) (2 trials)

fondaparinux sodium (arixtra) (2 trials)

ganciclovir (cytovene) (2 trials)

golimumab (simponi) (9 trials)

heroin (1 trial)

interferon alfacon-1 (Infergen) (1 trial)

letrozole (femara) (1 trial)

leucovorin (2 trials)

naloxone (narcan) (1 trial)

naltrexone (revia) (8 trials)

Nomegestrol acetate (1 trial)

paclitaxel (taxol) (2 trials)

rosuvastatin (crestor) (1 trial)

sch-58500 (2 trials)

testosterone (delatestryl) (4 trials)

urea (1 trial)

vardenafil (levitra) (2 trials)

vicriviroc (1 trial)

vincristine (oncovin) (2 trials)

Drugs in Phase 2 Trials (40)

Key: Schering-Plough (30) Acquired (10)

albuterol (proventil) (2 trials)

alemtuzumab (campath) (2 trials)

bevacizumab (avastin) (4 trials)

calcitriol (rocaltrol) (1 trial)

cisplatin (platinol) (1 trial)

dacarbazine (dtic-dome) (1 trial)

decitabine (dacogen) (4 trials)

didanosine (videx) (2 trials)

docetaxel (taxotere) (2 trials)

erlotinib (tarceva) (3 trials)

etoposide (vepesid) (1 trial)

everolimus (zortress) (2 trials)

fludarabine (fludara) (1 trial)

fluorouracil (efudex) (2 trials)

formoterol (foradil) (4 trials)

gemcitabine (gemzar) (1 trial)

heparin (liquaemin) (1 trial)

ibritumomab tiuxetan (Zevalin) (1 trial)

iloprost (ventavis) (1 trial)

imatinib (gleevec) (2 trials)

indacaterol (arcapta neohaler) (2 trials)

interferon alpha-2a (roferon-a) (1 trial)

irinotecan (Camptosar) (1 trial)

milrinone (primacor) (1 trial)

mirtazapine (remeron) (1 trial)

og-6219 (1 trial)

oxaliplatin (eloxatin) (1 trial)

oxymetazoline (ocuclear) (1 trial)

pembrolizumab (keytruda) (1 trial)

pravastatin (pravachol) (2 trials)

rolapitant (varubi) (1 trial)

sch66336 (9 trials)

sodium chloride (2 trials)

sorafenib (nexavar) (2 trials)

sunitinib (sutent) (2 trials)

temozolomide (temodar) (34 trials)

thiotepa (1 trial)

trastuzumab (herceptin) (2 trials)

vinblastine (velban) (1 trial)

zoledronic acid (zometa) (2 trials)

Drugs in Phase 1 Trials (17)

Key: Schering-Plough (12) Acquired (5)

azacitidine (vidaza) (1 trial)

bortezomib (velcade) (1 trial)

cyclosporine (sandimmune) (1 trial)

ficlatuzumab (1 trial)

follitropin beta (Follistim) (1 trial)

for-6219 (2 trials)

ketamine (ketalar) (1 trial)

lapatinib (tykerb) (1 trial)

n-(4-hydroxyphenyl)all-trans retinamide (1 trial)

o6-benzylguanine (1 trial)

org25435 (1 trial)

org-25935 (1 trial)

sch 39304 (1 trial)

topotecan (hycamtin) (1 trial)

valproic acid (depakene) (1 trial)

zalcitabine (hivid) (1 trial)

zidovudine (retrovir) (2 trials)

Drugs in Other Trials (5)

Key: Schering-Plough (3) Acquired (2)

human choriogonadotropin alfa (hCG) (1 trial)

oxytocin (syntocinon) (1 trial)

prednisone (meticorten) (1 trial)

protamine sulfate (1 trial)

rituximab (rituxan) (1 trial)

Indications

Approved Indications

Acne Vulgaris

Addison Disease

Adrenal Hyperplasia, Congenital

Aging

Anaphylaxis

Anemia, Aplastic

Anemia, Diamond-Blackfan

Arthritis, Rheumatoid

Aspergillosis

Asthma

Asthma, Exercise-Induced

Conjunctivitis, Allergic

Coronary Occlusion

Cough

Crohn Disease

Dermatitis, Allergic Contact

Dermatitis, Atopic

Dermatitis, Contact

Dermatitis, Exfoliative

Dermatitis Herpetiformis

Dermatitis, Seborrheic

Herpes Zoster Ophthalmicus

Lambert-Eaton Myasthenic Syndrome

Leukemia

Leukemia, Biphenotypic, Acute

Lupus Erythematosus, Systemic

Ophthalmia, Sympathetic

Optic Neuritis

Osteoarthritis

Osteoporosis, Postmenopausal

Primary Ovarian Insufficiency

Pruritus

Psoriasis

Pulmonary Disease, Chronic Obstructive

Pulmonary Edema

Pulmonary Embolism

Pulmonary Eosinophilia

Purpura, Thrombocytopenic, Idiopathic

Respiratory Distress Syndrome, Newborn

Rheumatic Diseases

Rhinitis, Allergic

Rhinitis, Allergic, Perennial

Rhinitis, Allergic, Seasonal

Spondylitis, Ankylosing

Stevens-Johnson Syndrome

Thyroiditis, Subacute

Trichinellosis

Tuberculosis, Meningeal

Tuberculosis, Pulmonary

Experimental Indications (Clinical Trials, Phases 1-4)

Acquired Immunodeficiency Syndrome (Phase 3)

Adenoma, Islet Cell (Phase 2)

Anemia (Phase 4)

Arteriosclerosis (Phase 4)

Arthritis (Phase 4)

Arthritis, Juvenile (Phase 3)

Arthritis, Psoriatic (Phase 3)

Arthritis, Rheumatoid (Phase 4)

Asthma (Phase 4)

Astrocytoma (Phase 2)

Atrial Fibrillation (Phase 4)

Brain Diseases (Phase 1)

Brain Neoplasms (Phase 2)

Breast Neoplasms (Phase 4)

Candidiasis (Phase 3)

Candidiasis, Oral (Phase 3)

Carcinoma (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Ovarian Epithelial (Phase 3)

Carcinoma, Renal Cell (Phase 2)

Carcinoma, Squamous Cell (Phase 1)

Central Nervous System Neoplasms (Phase 2)

Cerebrovascular Disorders (Phase 4)

Chronic Disease (Phase 4)

Cognitive Dysfunction (Phase 4)

Colorectal Neoplasms (Phase 1)

Communicable Diseases (Phase 4)

Coronary Artery Disease (Phase 4)

Coronary Disease (Phase 4)

Crohn Disease (Phase 4)

Cytomegalovirus Retinitis (Phase 3)

Depression (Phase 4)

Depressive Disorder (Phase 4)

Diabetes Mellitus (Phase 3)

Diabetes Mellitus, Type 2 (Phase 3)

Erectile Dysfunction (Phase 3)

Fallopian Tube Neoplasms (Phase 3)

Fibrosis (Phase 4)

Gastrointestinal Stromal Tumors (Phase 2)

Giant Cell Arteritis (Phase 3)

Glioblastoma (Phase 2)

Glioma (Phase 2)

Gliosarcoma (Phase 2)

Head and Neck Neoplasms (Phase 3)

Heart Diseases (Phase 4)

Hepatitis (Phase 4)

Hepatitis A (Phase 4)

Hepatitis B (Phase 3)

Hepatitis B, Chronic (Phase 3)

Hepatitis C (Phase 4)

Hepatitis C, Chronic (Phase 4)

Hepatitis, Chronic (Phase 4)

Heroin Dependence (Phase 4)

HIV Infections (Phase 3)

Hodgkin Disease (Phase 2)

Hypercholesterolemia (Phase 4)

Hypertension (Phase 4)

Hypoxia (Phase 2)

Immunologic Deficiency Syndromes (Phase 3)

Infarction (Phase 3)

Infections (Phase 4)

Inflammation (Phase 4)

Insulin Resistance (Phase 4)

Invasive Fungal Infections (Phase 4)

Kidney Diseases (Phase 4)

Kidney Neoplasms (Phase 1)

Leukemia (Phase 2)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)

Leukemia, Lymphoid (Phase 2)

Leukemia, Myelogenous, Chronic, BCR-ABL Positive (Phase 2)

Leukemia, Myeloid (Phase 2)

Leukemia, Myeloid, Acute (Phase 2)

Liver Cirrhosis (Phase 4)

Liver Diseases (Phase 2)

Lung Neoplasms (Phase 2)

Lymphoma (Phase 3)

Lymphoma, B-Cell (Phase 2)

Lymphoma, Non-Hodgkin (Phase 3)

Melanoma (Phase 3)

Meningeal Carcinomatosis (Phase 1)

Meningitis (Phase 1)

Meningitis, Cryptococcal (Phase 1)

Mesothelioma (Phase 1)

Mycoses (Phase 4)

Myocardial Infarction (Phase 3)

Myocardial Ischemia (Phase 4)

Myositis (Phase 3)

Nausea (Phase 2)

Neoplasm Metastasis (Phase 3)

Neoplasms (Phase 2)

Neoplasms, Second Primary (Phase 1)

Neoplasms, Squamous Cell (Phase 1)

Nervous System Neoplasms (Phase 2)

Neuroendocrine Tumors (Phase 2)

Neutropenia (Phase 4)

Oligodendroglioma (Phase 2)

Opioid-Related Disorders (Phase 3)

Osteosarcoma (Phase 2)

Ovarian Neoplasms (Phase 3)

Pancreatic Neoplasms (Phase 2)

Polymyalgia Rheumatica (Phase 3)

Progeria (Phase 2)

Psoriasis (Phase 4)

Psychomotor Agitation (Phase 4)

Recurrence (Phase 3)

Renal Insufficiency, Chronic (Phase 4)

Retinitis (Phase 3)

Rhinitis (Phase 4)

Rhinitis, Allergic (Phase 4)

Rhinitis, Allergic, Perennial (Phase 4)

Rhinitis, Allergic, Seasonal (Phase 4)

Sarcoma (Phase 2)

Sarcoma, Kaposi (Phase 2)

Scleroderma, Diffuse (Phase 2)

Scleroderma, Systemic (Phase 2)

Sclerosis (Phase 2)

Skin Neoplasms (Phase 2)

Small Cell Lung Carcinoma (Phase 2)

Spondylarthritis (Phase 3)

Spondylarthropathies (Phase 3)

Spondylitis (Phase 3)

Spondylitis, Ankylosing (Phase 3)

ST Elevation Myocardial Infarction (Phase 2)

Supratentorial Neoplasms (Phase 1)

Syndrome (Phase 2)

Telangiectasia, Hereditary Hemorrhagic (Phase 2)

Telangiectasis (Phase 2)

Virus Diseases (Phase 4)

Vomiting (Phase 2)

Xerostomia (Phase 3)

Overview

Highest Phase: Phase 4
# of Trials: 178
# of Trial APIs: 129