Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxidoreductases Acting on CH-NH Group Donors » Oxidoreductases, N-Demethylating » Cytochrome P-450 CYP3A
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 3 » Cytochrome P-450 CYP3A
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Oxidoreductases » Oxygenases » Mixed Function Oxygenases » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 3 » Cytochrome P-450 CYP3A
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Hemeproteins » Cytochromes » Cytochrome P-450 Enzyme System » Cytochrome P450 Family 3 » Cytochrome P-450 CYP3A
Description
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN. MeSH
Hierarchy View
Phase 4 Indicated Drugs (3)
Phase 1 Indicated Drugs (4)
Other Experimental Indicated Drugs (5)
Hierarchy Tree View
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