Phenomena and Processes [G] » Metabolism [G03] » Biotransformation » Inactivation, Metabolic » Metabolic Detoxication, Phase I
Phenomena and Processes [G] » Metabolism [G03] » Pharmacokinetics » Biotransformation » Inactivation, Metabolic » Metabolic Detoxication, Phase I
Phenomena and Processes [G] » Physiological Phenomena [G07] » Pharmacological and Toxicological Phenomena » Pharmacokinetics » Biotransformation » Inactivation, Metabolic » Metabolic Detoxication, Phase I
Description
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS. MeSH
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