Related MeSH Hierarchy (4)
Diseases [C] » Digestive System Diseases [C06] » Pancreatic Diseases » Congenital Hyperinsulinism » Nesidioblastosis
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Infant, Newborn, Diseases » Congenital Hyperinsulinism » Nesidioblastosis
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Glucose Metabolism Disorders » Hyperinsulinism » Congenital Hyperinsulinism » Nesidioblastosis
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Glucose Metabolism Disorders » Hypoglycemia » Congenital Hyperinsulinism » Nesidioblastosis
Description
An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11. MeSH
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