Related MeSH Hierarchy (7)
Diseases [C] » Nervous System Diseases [C10] » Cranial Nerve Diseases » Optic Nerve Diseases » Optic Atrophy » Optic Atrophies, Hereditary » Optic Atrophy, Hereditary, Leber
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Eye Diseases, Hereditary » Optic Atrophies, Hereditary » Optic Atrophy, Hereditary, Leber
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Heredodegenerative Disorders, Nervous System » Optic Atrophies, Hereditary » Optic Atrophy, Hereditary, Leber
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Mitochondrial Diseases » Optic Atrophy, Hereditary, Leber
Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Heredodegenerative Disorders, Nervous System » Optic Atrophies, Hereditary » Optic Atrophy, Hereditary, Leber
Diseases [C] » Eye Diseases [C11] » Eye Diseases, Hereditary » Optic Atrophies, Hereditary » Optic Atrophy, Hereditary, Leber
Diseases [C] » Eye Diseases [C11] » Optic Nerve Diseases » Optic Atrophy » Optic Atrophies, Hereditary » Optic Atrophy, Hereditary, Leber
Description
A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001)) MeSH
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Phase 4 Indicated Drugs (1)
Phase 2 Indicated Drugs (2)
Phase 1 Indicated Drugs (4)
Other Experimental Indicated Drugs (1)
Organization Involved with Phase 4 Indications (1)
Organization Involved with Phase 3 Indications (5)
Organization Involved with Phase 2 Indications (4)
Organization Involved with Phase 1 Indications (2)
Organization Involved with Other Experimental Indications (1)
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