Diseases [C] » Nervous System Diseases [C10] » Autonomic Nervous System Diseases » Primary Dysautonomias » Multiple System Atrophy » Striatonigral Degeneration
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Basal Ganglia Diseases » Multiple System Atrophy » Striatonigral Degeneration
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Movement Disorders » Multiple System Atrophy » Striatonigral Degeneration
Description
A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6) MeSH
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